Ion-biomolecule interactions and radiation damage

T.A. Schlathölter; F. Alvarado Chacon; R.A. Hoekstra

doi:10.1016/j.nimb.2005.03.087

Ion-biomolecule interactions and radiation damage

T.A. Schlathölter^*, F. Alvarado Chacon, R.A. Hoekstra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Scopus)

Abstract

Ionization and fragmentation of DNA and its constituents is it primary step in biological radiation damage. In this paper we investigate the response of nucleobases upon interaction with keV singly and multiply charged ions. The dependence of ionization and fragmentation on ion atomic number Z, charge state q and velocity r is investigated. The effect of the target molecule is discussed as well. (c) 2005 Published by Elsevier B.V.

Original language	English
Pages (from-to)	62-69
Number of pages	8
Journal	Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms
Volume	233
Issue number	1-4
DOIs	https://doi.org/10.1016/j.nimb.2005.03.087
Publication status	Published - May-2005
Event	8th Workshop on Fast Ion-Atom Collisions - , Hungary Duration: 1-Sept-2004 → 3-Sept-2004

Keywords

nucleobases
highly charged ions
time-of-flight spcctrometry
DNA STRAND BREAKS
ELECTRON-ATTACHMENT
FRAGMENTATION
COLLISIONS
THERAPY
THYMINE
BASES

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Cite this

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title = "Ion-biomolecule interactions and radiation damage",

abstract = "Ionization and fragmentation of DNA and its constituents is it primary step in biological radiation damage. In this paper we investigate the response of nucleobases upon interaction with keV singly and multiply charged ions. The dependence of ionization and fragmentation on ion atomic number Z, charge state q and velocity r is investigated. The effect of the target molecule is discussed as well. (c) 2005 Published by Elsevier B.V.",

keywords = "nucleobases, highly charged ions, time-of-flight spcctrometry, DNA STRAND BREAKS, ELECTRON-ATTACHMENT, FRAGMENTATION, COLLISIONS, THERAPY, THYMINE, BASES",

author = "T.A. Schlath{\"o}lter and {Alvarado Chacon}, F. and R.A. Hoekstra",

year = "2005",

month = may,

doi = "10.1016/j.nimb.2005.03.087",

language = "English",

volume = "233",

pages = "62--69",

journal = "Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms",

issn = "0168-583X",

publisher = "ELSEVIER SCIENCE BV",

number = "1-4",

note = "8th Workshop on Fast Ion-Atom Collisions ; Conference date: 01-09-2004 Through 03-09-2004",

}

TY - JOUR

T1 - Ion-biomolecule interactions and radiation damage

AU - Schlathölter, T.A.

AU - Alvarado Chacon, F.

AU - Hoekstra, R.A.

PY - 2005/5

Y1 - 2005/5

N2 - Ionization and fragmentation of DNA and its constituents is it primary step in biological radiation damage. In this paper we investigate the response of nucleobases upon interaction with keV singly and multiply charged ions. The dependence of ionization and fragmentation on ion atomic number Z, charge state q and velocity r is investigated. The effect of the target molecule is discussed as well. (c) 2005 Published by Elsevier B.V.

AB - Ionization and fragmentation of DNA and its constituents is it primary step in biological radiation damage. In this paper we investigate the response of nucleobases upon interaction with keV singly and multiply charged ions. The dependence of ionization and fragmentation on ion atomic number Z, charge state q and velocity r is investigated. The effect of the target molecule is discussed as well. (c) 2005 Published by Elsevier B.V.

KW - nucleobases

KW - highly charged ions

KW - time-of-flight spcctrometry

KW - DNA STRAND BREAKS

KW - ELECTRON-ATTACHMENT

KW - FRAGMENTATION

KW - COLLISIONS

KW - THERAPY

KW - THYMINE

KW - BASES

U2 - 10.1016/j.nimb.2005.03.087

DO - 10.1016/j.nimb.2005.03.087

M3 - Article

SN - 0168-583X

VL - 233

SP - 62

EP - 69

JO - Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms

JF - Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms

IS - 1-4

T2 - 8th Workshop on Fast Ion-Atom Collisions

Y2 - 1 September 2004 through 3 September 2004

ER -