Ion-induced biomolecular radiation damage: From isolated nucleobases to nucleobase clusters

T.A. Schlathölter; F. Alvarado; S. Bari; A. Lecointre; R.A. Hoekstra; V. Bernigaud; B. Manil; J. Rangama; B. Huber

doi:10.1002/cphc.200600361

Ion-induced biomolecular radiation damage: From isolated nucleobases to nucleobase clusters

T.A. Schlathölter^*, F. Alvarado, S. Bari, A. Lecointre, R.A. Hoekstra, V. Bernigaud, B. Manil, J. Rangama, B. Huber

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

88 Citations (Scopus)

Abstract

A large number of studies ore devoted to the investigation of the biomolecular ionization and fragmentation dynamics underlying biological radiation damage. Most of these studies have been based on gas-phose collisions with isolated DNA building blocks. The rodiobiologicol significance of these studies is often questioned because of the lock of a chemical environment. To clarify this aspect, we studied interactions of keV ions with isolated nucleobases and with nucleobase clusters by means of coincidence time-of-flight spectrometry. Significant changes already show up in the molecular fragmentation patterns of very small clusters.

Original language	English
Pages (from-to)	2339-2345
Number of pages	7
Journal	Physical Chemistry Chemical Physics
Volume	7
Issue number	11
DOIs	https://doi.org/10.1002/cphc.200600361
Publication status	Published - 13-Nov-2006

Keywords

clusters
fragmentation reactions
hydrogen bonds
ions
nucleobases
NUCLEIC ACID DERIVATIVES
DNA STRAND BREAKS
IONIZATION-POTENTIALS
HOMOPAIRING POSSIBILITIES
ELECTRON-ATTACHMENT
AQUEOUS-SOLUTION
BASE THYMINE
MASS SPECTRA
ADENINE
FRAGMENTATION

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Ion-induced biomolecular radiation damage From isolated nucleobases
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title = "Ion-induced biomolecular radiation damage: From isolated nucleobases to nucleobase clusters",

abstract = "A large number of studies ore devoted to the investigation of the biomolecular ionization and fragmentation dynamics underlying biological radiation damage. Most of these studies have been based on gas-phose collisions with isolated DNA building blocks. The rodiobiologicol significance of these studies is often questioned because of the lock of a chemical environment. To clarify this aspect, we studied interactions of keV ions with isolated nucleobases and with nucleobase clusters by means of coincidence time-of-flight spectrometry. Significant changes already show up in the molecular fragmentation patterns of very small clusters.",

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author = "T.A. Schlath{\"o}lter and F. Alvarado and S. Bari and A. Lecointre and R.A. Hoekstra and V. Bernigaud and B. Manil and J. Rangama and B. Huber",

year = "2006",

month = nov,

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doi = "10.1002/cphc.200600361",

language = "English",

volume = "7",

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journal = "Physical Chemistry Chemical Physics",

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T1 - Ion-induced biomolecular radiation damage

T2 - From isolated nucleobases to nucleobase clusters

AU - Schlathölter, T.A.

AU - Alvarado, F.

AU - Bari, S.

AU - Lecointre, A.

AU - Hoekstra, R.A.

AU - Bernigaud, V.

AU - Manil, B.

AU - Rangama, J.

AU - Huber, B.

PY - 2006/11/13

Y1 - 2006/11/13

N2 - A large number of studies ore devoted to the investigation of the biomolecular ionization and fragmentation dynamics underlying biological radiation damage. Most of these studies have been based on gas-phose collisions with isolated DNA building blocks. The rodiobiologicol significance of these studies is often questioned because of the lock of a chemical environment. To clarify this aspect, we studied interactions of keV ions with isolated nucleobases and with nucleobase clusters by means of coincidence time-of-flight spectrometry. Significant changes already show up in the molecular fragmentation patterns of very small clusters.

AB - A large number of studies ore devoted to the investigation of the biomolecular ionization and fragmentation dynamics underlying biological radiation damage. Most of these studies have been based on gas-phose collisions with isolated DNA building blocks. The rodiobiologicol significance of these studies is often questioned because of the lock of a chemical environment. To clarify this aspect, we studied interactions of keV ions with isolated nucleobases and with nucleobase clusters by means of coincidence time-of-flight spectrometry. Significant changes already show up in the molecular fragmentation patterns of very small clusters.

KW - clusters

KW - fragmentation reactions

KW - hydrogen bonds

KW - ions

KW - nucleobases

KW - NUCLEIC ACID DERIVATIVES

KW - DNA STRAND BREAKS

KW - IONIZATION-POTENTIALS

KW - HOMOPAIRING POSSIBILITIES

KW - ELECTRON-ATTACHMENT

KW - AQUEOUS-SOLUTION

KW - BASE THYMINE

KW - MASS SPECTRA

KW - ADENINE

KW - FRAGMENTATION

U2 - 10.1002/cphc.200600361

DO - 10.1002/cphc.200600361

M3 - Article

SN - 1463-9084

VL - 7

SP - 2339

EP - 2345

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

IS - 11

ER -

Ion-induced biomolecular radiation damage: From isolated nucleobases to nucleobase clusters

Abstract

Keywords

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