Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma

H. Maazi, S. Shirinbak, N. Bloksma, M. C. Nawijn, A. J. M. van Oosterhout*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Abstract

The prevalence of allergic diseases has increased dramatically during the last four decades and is paralleled by a striking increase in iron intake by infants in affluent societies. Several studies have suggested a link between increased iron intake and the marked increase in prevalence of allergic diseases. We hypothesized that the increased iron intake by infants offers an explanation for the increased prevalence of allergic disease in industrialized societies during the past four decades. A well-established mouse model of ovalbumin (OVA)-driven allergic asthma was used to test the effects of differences in iron intake and systemic iron levels on the manifestations of allergic asthma. Surprisingly, iron supplementation resulted in a significant decrease in airway eosinophilia, while systemic iron injections lead to a significant suppression of both allergen-induced airway eosinophilia and hyperreactivity compared to placebo. In contrast, mice fed on an iron-deprived diet did not show any difference in developing experimentally induced allergic asthma when compared to those fed on an iron-sufficient control diet. In contrast to our hypothesis, airway manifestations of allergic asthma are suppressed by both increased levels of iron intake and systemic iron administrations in the mouse model.

Original languageEnglish
Pages (from-to)80-86
Number of pages7
JournalClinical and Experimental Immunology
Volume166
Issue number1
DOIs
Publication statusPublished - Oct-2011

Keywords

  • airway hyperreactivity
  • allergy
  • asthma
  • dietary iron
  • eosinophilia
  • CANDIDA-ALBICANS
  • BINDING-CAPACITY
  • INFANT FORMULAS
  • MURINE MODEL
  • OVERLOAD
  • INFLAMMATION
  • MICE
  • IMMUNOTHERAPY
  • FORTIFICATION
  • ABSORPTION

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