Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use

Haye H. van der Wal; Niels Grote Beverborg; Kenneth Dickstein; Stefan D. Anker; Chim C. Lang; Leong L. Ng; Dirk J. van Veldhuisen; Adriaan A. Voors; Peter van der Meer

doi:10.1093/eurheartj/ehz680

Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use

Haye H. van der Wal, Niels Grote Beverborg, Kenneth Dickstein, Stefan D. Anker, Chim C. Lang, Leong L. Ng, Dirk J. van Veldhuisen, Adriaan A. Voors, Peter van der Meer^*

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

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Abstract

Aims Iron deficiency (ID) is common in heart failure (HF) patients and negatively impacts symptoms and prognosis. The aetiology of ID in HF is largely unknown. We studied determinants and the biomarker profile of ID in a large international HF cohort.

Methods and results We studied 2357 worsening HF patients from the BIOSTAT-CHF cohort. ID was defined as transferrin saturation

Conclusion Our data suggest that the aetiology of ID in worsening HF is complex, multifactorial and seems to consist of a combination of reduced iron uptake (malnutrition, fluid overload), impaired iron storage (inflammation, chronic kidney disease), and iron loss (antiplatelets).

Original language	English
Pages (from-to)	3616-3625
Number of pages	10
Journal	European Heart Journal
Volume	40
Issue number	44
DOIs	https://doi.org/10.1093/eurheartj/ehz680
Publication status	Published - 21-Nov-2019

Keywords

Heart failure
Iron deficiency
Inflammation
Protein intake
Fluid retention
Antiplatelets
NUTRITIONAL-STATUS
PROGNOSTIC IMPACT
MALNUTRITION
ANEMIA
INDEX
MICE
PARAOXONASE
PREVALENCE
MORTALITY
CACHEXIA

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Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet useFinal publisher's version, 499 KBLicence: CC BY-NC

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van der Wal, H. H., Grote Beverborg, N., Dickstein, K., Anker, S. D., Lang, C. C., Ng, L. L., van Veldhuisen, D. J., Voors, A. A., & van der Meer, P. (2019). Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use. European Heart Journal, 40(44), 3616-3625. https://doi.org/10.1093/eurheartj/ehz680

van der Wal, Haye H. ; Grote Beverborg, Niels ; Dickstein, Kenneth ; Anker, Stefan D. ; Lang, Chim C. ; Ng, Leong L. ; van Veldhuisen, Dirk J. ; Voors, Adriaan A. ; van der Meer, Peter. / Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use. In: European Heart Journal. 2019 ; Vol. 40, No. 44. pp. 3616-3625.

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title = "Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use",

abstract = "Aims Iron deficiency (ID) is common in heart failure (HF) patients and negatively impacts symptoms and prognosis. The aetiology of ID in HF is largely unknown. We studied determinants and the biomarker profile of ID in a large international HF cohort.Methods and results We studied 2357 worsening HF patients from the BIOSTAT-CHF cohort. ID was defined as transferrin saturationConclusion Our data suggest that the aetiology of ID in worsening HF is complex, multifactorial and seems to consist of a combination of reduced iron uptake (malnutrition, fluid overload), impaired iron storage (inflammation, chronic kidney disease), and iron loss (antiplatelets).",

keywords = "Heart failure, Iron deficiency, Inflammation, Protein intake, Fluid retention, Antiplatelets, NUTRITIONAL-STATUS, PROGNOSTIC IMPACT, MALNUTRITION, ANEMIA, INDEX, MICE, PARAOXONASE, PREVALENCE, MORTALITY, CACHEXIA",

author = "{van der Wal}, {Haye H.} and {Grote Beverborg}, Niels and Kenneth Dickstein and Anker, {Stefan D.} and Lang, {Chim C.} and Ng, {Leong L.} and {van Veldhuisen}, {Dirk J.} and Voors, {Adriaan A.} and {van der Meer}, Peter",

year = "2019",

month = nov,

day = "21",

doi = "10.1093/eurheartj/ehz680",

language = "English",

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van der Wal, HH, Grote Beverborg, N, Dickstein, K, Anker, SD, Lang, CC, Ng, LL, van Veldhuisen, DJ , Voors, AA & van der Meer, P 2019, 'Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use', European Heart Journal, vol. 40, no. 44, pp. 3616-3625. https://doi.org/10.1093/eurheartj/ehz680

Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use. / van der Wal, Haye H.; Grote Beverborg, Niels; Dickstein, Kenneth; Anker, Stefan D.; Lang, Chim C.; Ng, Leong L.; van Veldhuisen, Dirk J.; Voors, Adriaan A.; van der Meer, Peter.

In: European Heart Journal, Vol. 40, No. 44, 21.11.2019, p. 3616-3625.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use

AU - van der Wal, Haye H.

AU - Grote Beverborg, Niels

AU - Dickstein, Kenneth

AU - Anker, Stefan D.

AU - Lang, Chim C.

AU - Ng, Leong L.

AU - van Veldhuisen, Dirk J.

AU - Voors, Adriaan A.

AU - van der Meer, Peter

PY - 2019/11/21

Y1 - 2019/11/21

N2 - Aims Iron deficiency (ID) is common in heart failure (HF) patients and negatively impacts symptoms and prognosis. The aetiology of ID in HF is largely unknown. We studied determinants and the biomarker profile of ID in a large international HF cohort.Methods and results We studied 2357 worsening HF patients from the BIOSTAT-CHF cohort. ID was defined as transferrin saturationConclusion Our data suggest that the aetiology of ID in worsening HF is complex, multifactorial and seems to consist of a combination of reduced iron uptake (malnutrition, fluid overload), impaired iron storage (inflammation, chronic kidney disease), and iron loss (antiplatelets).

AB - Aims Iron deficiency (ID) is common in heart failure (HF) patients and negatively impacts symptoms and prognosis. The aetiology of ID in HF is largely unknown. We studied determinants and the biomarker profile of ID in a large international HF cohort.Methods and results We studied 2357 worsening HF patients from the BIOSTAT-CHF cohort. ID was defined as transferrin saturationConclusion Our data suggest that the aetiology of ID in worsening HF is complex, multifactorial and seems to consist of a combination of reduced iron uptake (malnutrition, fluid overload), impaired iron storage (inflammation, chronic kidney disease), and iron loss (antiplatelets).

KW - Heart failure

KW - Iron deficiency

KW - Inflammation

KW - Protein intake

KW - Fluid retention

KW - Antiplatelets

KW - NUTRITIONAL-STATUS

KW - PROGNOSTIC IMPACT

KW - MALNUTRITION

KW - ANEMIA

KW - INDEX

KW - MICE

KW - PARAOXONASE

KW - PREVALENCE

KW - MORTALITY

KW - CACHEXIA

U2 - 10.1093/eurheartj/ehz680

DO - 10.1093/eurheartj/ehz680

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JF - European Heart Journal

SN - 0195-668X

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ER -