Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis

Marcus Miethke, Helga Westers, Evert-Jan Blom, Oscar P. Kuipers, Mohamed A. Marahiel*

*Corresponding author for this work

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Abstract

Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur) The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production.

Original languageEnglish
Pages (from-to)8655-8657
Number of pages3
JournalJournal of Bacteriology
Volume188
Issue number24
DOIs
Publication statusPublished - Dec-2006

Keywords

  • GLUTAMATE SYNTHASE
  • ESCHERICHIA-COLI
  • NITROGEN-SOURCE
  • CITB GENE
  • OPERON
  • REPRESSION
  • REGULATOR
  • BACTERIA
  • GLUCOSE
  • REGULON

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