Abstract
Background. In glomerular disease proteinuria usually has a circadian pattern with maximum excretion during the day. Blockade of the renin-angiotensin system (RAS) results in a 50% reduction of proteinuria as measured in 24-h urine collections. We questioned whether anti-proteinuric treatment by blockade of the RAS is as effective during the day as during the night.
Methods. We analysed data from two intervention studies on proteinuria in patients with non-diabetic renal disease. In the first study, six hospitalized patients (proteinuria 5.8+/-2.9 g/day) were treated with the renin-inhibitor remikiren 600 mg o.d. during 8 days. In the second study eight ambulant patients (proteinuria 7.5+/-2.7 g/day) were treated during 6 weeks with the ACE-inhibitor trandolapril 4 mg o.d. Urine was collected in a day-and in a night-time portion.
Results. Daytime proteinuria declined from 0.29+/-0.15 to 0.22+/-0.11 g/h (P <0.05) during remikiren and from 0.33 +/- 0.14 to 0.16+/-0.08 g/h (P
Conclusion. In both studies relative nocturnal therapy resistance to the antiproteinuric effect of RAS blockade was found, despite 24-h efficacy of blood pressure effect. This may have clinical relevance because it contributes to rest-proteinuria and thus may affect long term renal function outcome. It may be worthwhile to explore alternative therapeutic regimens to improve the nocturnal antiproteinuric response.
| Original language | English |
|---|---|
| Pages (from-to) | 53-56 |
| Number of pages | 4 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 12 |
| Issue number | Suppl. 2 |
| Publication status | Published - 1997 |
| Event | 3rd International Symposium on Proteinuria and Progressive Renal Disease - , Netherlands Duration: 1-Jun-1996 → … |
Keywords
- ACE-inhibitor
- circadian pattern
- proteinuria
- renin-angiotensin system
- renin-inhibitor
- CONVERTING-ENZYME
- CIRCADIAN-RHYTHM
- BLOOD-PRESSURE
- NEPHROTIC SYNDROME
- URINARY PROTEIN