Ischaemic colitis and lung infiltrates caused by extramedullary haematopoiesis in a patient with an acute erythroid leukaemia following polycythaemia vera

SJL Brada*, JTM de Wolf, S Poppema, E Vellenga

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    4 Citations (Scopus)

    Abstract

    A patient with 'spent' polycythaemia vera showed extensive extramedullary haematopoiesis (EMH) in non-haematopoietic tissue clinically resulting in an ischaemic colitis and respiratory symptoms due to lung infiltrates. On laboratory investigation, the EMH also included immature erythroblasts due to acute erythroid leukaemia. It is hypothesised that the abnormal homing of erythroid progenitors might be related to the abnormal expression of antigens, such as CD36. (C) 1998 Elsevier Science B.V.

    Original languageEnglish
    Pages (from-to)142-146
    Number of pages5
    JournalNetherlands Journal of Medicine
    Volume52
    Issue number4
    Publication statusPublished - Apr-1998

    Keywords

    • polycythemia vera (PV)
    • extramedullary hematopoiesis (EMH)
    • acute leukemia (AL)
    • CD36
    • AGNOGENIC MYELOID METAPLASIA
    • POLYCYTHEMIA-VERA
    • ACUTE-LEUKEMIA
    • PLASMODIUM-FALCIPARUM
    • ENDOTHELIAL-CELLS
    • SPLENECTOMY
    • MYELOFIBROSIS
    • PROGENITORS
    • BLOOD

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