Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

Gertrude J Nieuwenhuijs-Moeke*, Søren E Pischke, Stefan P Berger, Jan Stephan F Sanders, Robert A Pol, Michel M R F Struys, Rutger J Ploeg, Henri G D Leuvenink

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

34 Citations (Scopus)
56 Downloads (Pure)

Abstract

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.

Original languageEnglish
Article number253
Number of pages33
JournalJournal of Clinical Medicine
Volume9
Issue number1
DOIs
Publication statusPublished - 17-Jan-2020

Keywords

  • ischemia reperfusion injury
  • kidney transplantation
  • delayed graft function
  • innate immune system
  • adaptive immune system
  • apoptosis
  • necrosis
  • hypoxic inducible factor
  • endothelial dysfunction
  • REGULATORY T-CELLS
  • HYPOXIA-INDUCIBLE FACTOR-1-ALPHA
  • ANTIBODY-MEDIATED REJECTION
  • DELAYED GRAFT FUNCTION
  • MESENCHYMAL TRANSITION
  • RECEPTOR 4
  • IMMUNE-RESPONSES
  • DENDRITIC CELLS
  • INNATE IMMUNITY
  • IN-VIVO

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