Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

Gertrude J Nieuwenhuijs-Moeke; Søren E Pischke; Stefan P Berger; Jan Stephan F Sanders; Robert A Pol; Michel M R F Struys; Rutger J Ploeg; Henri G D Leuvenink

doi:10.3390/jcm9010253

Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

Gertrude J Nieuwenhuijs-Moeke^*, Søren E Pischke, Stefan P Berger, Jan Stephan F Sanders, Robert A Pol, Michel M R F Struys, Rutger J Ploeg, Henri G D Leuvenink

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

228 Citations (Scopus)

281 Downloads (Pure)

Abstract

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.

Original language	English
Article number	253
Number of pages	33
Journal	Journal of Clinical Medicine
Volume	9
Issue number	1
DOIs	https://doi.org/10.3390/jcm9010253
Publication status	Published - 17-Jan-2020

Keywords

ischemia reperfusion injury
kidney transplantation
delayed graft function
innate immune system
adaptive immune system
apoptosis
necrosis
hypoxic inducible factor
endothelial dysfunction
REGULATORY T-CELLS
HYPOXIA-INDUCIBLE FACTOR-1-ALPHA
ANTIBODY-MEDIATED REJECTION
DELAYED GRAFT FUNCTION
MESENCHYMAL TRANSITION
RECEPTOR 4
IMMUNE-RESPONSES
DENDRITIC CELLS
INNATE IMMUNITY
IN-VIVO

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title = "Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair",

abstract = "Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.",

keywords = "ischemia reperfusion injury, kidney transplantation, delayed graft function, innate immune system, adaptive immune system, apoptosis, necrosis, hypoxic inducible factor, endothelial dysfunction, REGULATORY T-CELLS, HYPOXIA-INDUCIBLE FACTOR-1-ALPHA, ANTIBODY-MEDIATED REJECTION, DELAYED GRAFT FUNCTION, MESENCHYMAL TRANSITION, RECEPTOR 4, IMMUNE-RESPONSES, DENDRITIC CELLS, INNATE IMMUNITY, IN-VIVO",

author = "Nieuwenhuijs-Moeke, {Gertrude J} and Pischke, {S{\o}ren E} and Berger, {Stefan P} and Sanders, {Jan Stephan F} and Pol, {Robert A} and Struys, {Michel M R F} and Ploeg, {Rutger J} and Leuvenink, {Henri G D}",

year = "2020",

month = jan,

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doi = "10.3390/jcm9010253",

language = "English",

volume = "9",

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T1 - Ischemia and Reperfusion Injury in Kidney Transplantation

T2 - Relevant Mechanisms in Injury and Repair

AU - Nieuwenhuijs-Moeke, Gertrude J

AU - Pischke, Søren E

AU - Berger, Stefan P

AU - Sanders, Jan Stephan F

AU - Pol, Robert A

AU - Struys, Michel M R F

AU - Ploeg, Rutger J

AU - Leuvenink, Henri G D

PY - 2020/1/17

Y1 - 2020/1/17

N2 - Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.

AB - Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.

KW - ischemia reperfusion injury

KW - kidney transplantation

KW - delayed graft function

KW - innate immune system

KW - adaptive immune system

KW - apoptosis

KW - necrosis

KW - hypoxic inducible factor

KW - endothelial dysfunction

KW - REGULATORY T-CELLS

KW - HYPOXIA-INDUCIBLE FACTOR-1-ALPHA

KW - ANTIBODY-MEDIATED REJECTION

KW - DELAYED GRAFT FUNCTION

KW - MESENCHYMAL TRANSITION

KW - RECEPTOR 4

KW - IMMUNE-RESPONSES

KW - DENDRITIC CELLS

KW - INNATE IMMUNITY

KW - IN-VIVO

U2 - 10.3390/jcm9010253

DO - 10.3390/jcm9010253

M3 - Review article

C2 - 31963521

SN - 2077-0383

VL - 9

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 1

M1 - 253

ER -

Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

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