Isocyanide-Based Multicomponent Reactions of Free Phenylboronic Acids

Constantinos G. Neochoritis, Tryfon Zarganes-Tzitzikas, Michaela Novotna, Tatiana Mitrikova, Zefeng Wang, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Alexander Domling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Boronic acids are amongst the most useful synthetic intermediates, frequently used by modern drug design. However, their access and fast synthesis of libraries are often problematic. We present a methodology on the synthesis of drug-like scaffolds via IMCRs with unprotected phenylboronic acids. To demonstrate an application of our approach, we also performed one-pot Suzuki couplings on the primary MCR scaffolds. Moreover, we performed a thorough data-mining of the Cambridge Structural Database, revealing interesting geometrical features.

Original languageEnglish
Pages (from-to)6132-6137
Number of pages6
JournalEuropean Journal of Organic Chemistry
Volume2019
Issue number35
DOIs
Publication statusPublished - 22-Sep-2019

Keywords

  • Multicomponent reactions
  • Boron
  • Ugi reaction
  • C-C coupling
  • Structure elucidation
  • BORONIC ACIDS
  • PYRAZINES
  • PLATFORM
  • ANALOGS

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