Isolation of two cytotoxic diterpenes from the fern Pteris multifida

HJ Woerdenbag*, LR Lutke, R Bos, JF Stevens, R Hulst, WH Kruizinga, ET Elema, H Hendriks, W vanUden, N Pras

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, ent-kaurane-2 beta,16 alpha-diol and ent-kaur-16-ene-2 beta,15 alpha-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.

Original languageEnglish
Pages (from-to)635-638
Number of pages4
JournalZeitschrift fur naturforschung c-A journal of biosciences
Volume51
Issue number9-10
Publication statusPublished - 1996

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