Isolation of two cytotoxic diterpenes from the fern Pteris multifida

HJ Woerdenbag; LR Lutke; R Bos; JF Stevens; R Hulst; WH Kruizinga; ET Elema; H Hendriks; W vanUden; N Pras

Isolation of two cytotoxic diterpenes from the fern Pteris multifida

HJ Woerdenbag^*
, LR Lutke
, R Bos
, JF Stevens
, R Hulst
, WH Kruizinga
, ET Elema
, H Hendriks
, W vanUden
, N Pras

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, ent-kaurane-2 beta,16 alpha-diol and ent-kaur-16-ene-2 beta,15 alpha-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.

Original language	English
Pages (from-to)	635-638
Number of pages	4
Journal	Zeitschrift fur naturforschung c-A journal of biosciences
Volume	51
Issue number	9-10
Publication status	Published - 1996

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title = "Isolation of two cytotoxic diterpenes from the fern Pteris multifida",

abstract = "From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, ent-kaurane-2 beta,16 alpha-diol and ent-kaur-16-ene-2 beta,15 alpha-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.",

author = "HJ Woerdenbag and LR Lutke and R Bos and JF Stevens and R Hulst and WH Kruizinga and ET Elema and H Hendriks and W vanUden and N Pras",

year = "1996",

language = "English",

volume = "51",

pages = "635--638",

journal = "Zeitschrift fur naturforschung c-A journal of biosciences",

issn = "0939-5075",

number = "9-10",

}

TY - JOUR

T1 - Isolation of two cytotoxic diterpenes from the fern Pteris multifida

AU - Woerdenbag, HJ

AU - Lutke, LR

AU - Bos, R

AU - Stevens, JF

AU - Hulst, R

AU - Kruizinga, WH

AU - Elema, ET

AU - Hendriks, H

AU - vanUden, W

AU - Pras, N

PY - 1996

Y1 - 1996

N2 - From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, ent-kaurane-2 beta,16 alpha-diol and ent-kaur-16-ene-2 beta,15 alpha-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.

AB - From aerial parts of the fern Pteris multifida Poir. (Polypodiaceae) two diterpenes, ent-kaurane-2 beta,16 alpha-diol and ent-kaur-16-ene-2 beta,15 alpha-diol, were isolated by repeated column chromatography using silica gel and silica gel impregnated with silver nitrate. The structures were confirmed by spectroscopic methods. Both compounds showed a moderate cytotoxicity to Ehrlich ascites tumour cells.

M3 - Article

SN - 0939-5075

VL - 51

SP - 635

EP - 638

JO - Zeitschrift fur naturforschung c-A journal of biosciences

JF - Zeitschrift fur naturforschung c-A journal of biosciences

IS - 9-10

ER -

Isolation of two cytotoxic diterpenes from the fern Pteris multifida

Abstract

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