Isomeric effects in ion-induced fragmentation of alpha- and beta-alanine

P. Sobocinski*, S. Bari, J. Postma, F. Alvarado, R. Hoekstra, B. Manil, J. Rangama, V. Bernigaud, B. A. Huber, T. Schlatholter

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    3 Citations (Scopus)
    30 Downloads (Pure)

    Abstract

    We have investigated the dissociation of alpha- and beta- alanine following impact of slow multicharged ions, namely He(+), He(2+), O(5+) and Xe(20+) at 10 keV per charge unit. The collision products were analyzed using a reflectron-type time-of-flight mass spectrometer. In general, for a given projectile, ionization of both alanine-isomers gives rise to similar fragmentation patterns. However, significantly different peak intensities are observed for fragments with mass over charge ratios (m/q) of 30 and 44 amu. These differences can be explained in terms of isomer geometry and fragment stability. By analyzing the fragment kinetic energies, we found that protons as well as ionic oxygen fragments are sufficiently energetic (up to 200 eV for Xe(20+)) to induce further damage in a biological environment.

    Original languageEnglish
    Title of host publicationRADIATION DAMAGE IN BIOMOLECULAR SYSTEMS
    EditorsKG McGuigan, K Tokesi, B Sulik
    Place of PublicationBRISTOL
    PublisherIOP PUBLISHING LTD
    Number of pages6
    DOIs
    Publication statusPublished - 2008
    EventCOST Action P9 Meeting on Radiation Damage in Biomolecular Systems - , Ireland
    Duration: 19-Jul-200722-Jul-2007

    Publication series

    NameJournal of Physics Conference Series
    PublisherIOP PUBLISHING LTD
    Volume101
    ISSN (Print)1742-6588

    Other

    OtherCOST Action P9 Meeting on Radiation Damage in Biomolecular Systems
    Country/TerritoryIreland
    Period19/07/200722/07/2007

    Keywords

    • DNA STRAND BREAKS
    • ELECTRON-ATTACHMENT
    • THYMINE
    • DAMAGE
    • BASES

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