Isomeric effects in ion-induced fragmentation of alpha- and beta-alanine

P. Sobocinski*, S. Bari, J. Postma, F. Alvarado, R. Hoekstra, B. Manil, J. Rangama, V. Bernigaud, B. A. Huber, T. Schlatholter

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

3 Citations (Scopus)

Abstract

We have investigated the dissociation of alpha- and beta- alanine following impact of slow multicharged ions, namely He(+), He(2+), O(5+) and Xe(20+) at 10 keV per charge unit. The collision products were analyzed using a reflectron-type time-of-flight mass spectrometer. In general, for a given projectile, ionization of both alanine-isomers gives rise to similar fragmentation patterns. However, significantly different peak intensities are observed for fragments with mass over charge ratios (m/q) of 30 and 44 amu. These differences can be explained in terms of isomer geometry and fragment stability. By analyzing the fragment kinetic energies, we found that protons as well as ionic oxygen fragments are sufficiently energetic (up to 200 eV for Xe(20+)) to induce further damage in a biological environment.

Original languageEnglish
Title of host publicationRADIATION DAMAGE IN BIOMOLECULAR SYSTEMS
EditorsKG McGuigan, K Tokesi, B Sulik
Place of PublicationBRISTOL
PublisherIOP PUBLISHING LTD
Number of pages6
ISBN (Print)*****************
DOIs
Publication statusPublished - 2008
EventCOST Action P9 Meeting on Radiation Damage in Biomolecular Systems - , Ireland
Duration: 19-Jul-200722-Jul-2007

Publication series

NameJournal of Physics Conference Series
PublisherIOP PUBLISHING LTD
Volume101
ISSN (Print)1742-6588

Other

OtherCOST Action P9 Meeting on Radiation Damage in Biomolecular Systems
Country/TerritoryIreland
Period19/07/200722/07/2007

Keywords

  • DNA STRAND BREAKS
  • ELECTRON-ATTACHMENT
  • THYMINE
  • DAMAGE
  • BASES

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