Joint Multi-modal Parcellation of the Human Striatum: Functions and Clinical Relevance

Xiaojin Liu, Simon B. Eickhoff, Felix Hoffstaedter, Sarah Genon, Svenja Caspers, Kathrin Reetz, Imis Dogan, Claudia R. Eickhoff, Ji Chen, Julian Caspers, Niels Reuter, Christian Mathys, Andre Aleman, Renaud Jardri, Valentin Riedl, Iris E. Sommer, Kaustubh R. Patil*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
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Abstract

The human striatum is essential for both low- and high-level functions and has been implicated in the pathophysiology of various prevalent disorders, including Parkinson's disease (PD) and schizophrenia (SCZ). It is known to consist of structurally and functionally divergent subdivisions. However, previous parcellations are based on a single neuroimaging modality, leaving the extent of the multi-modal organization of the striatum unknown. Here, we investigated the organization of the striatum across three modalities-resting-state functional connectivity, probabilistic diffusion tractography, and structural covariance-to provide a holistic convergent view of its structure and function. We found convergent clusters in the dorsal, dorsolateral, rostral, ventral, and caudal striatum. Functional characterization revealed the anterior striatum to be mainly associated with cognitive and emotional functions, while the caudal striatum was related to action execution. Interestingly, significant structural atrophy in the rostral and ventral striatum was common to both PD and SCZ, but atrophy in the dorsolateral striatum was specifically attributable to PD. Our study revealed a cross-modal convergent organization of the striatum, representing a fundamental topographical model that can be useful for investigating structural and functional variability in aging and in clinical conditions.

Original languageEnglish
Pages (from-to)1123-1136
Number of pages14
JournalNeuroscience bulletin
Volume36
Issue number10
Early online date23-Jul-2020
DOIs
Publication statusPublished - Oct-2020

Keywords

  • Striatum
  • Multi-modal
  • Connectivity-based parcellation
  • Convergent clusters
  • Voxel-based morphometry
  • Parkinson's disease
  • Schizophrenia
  • CONNECTIVITY-BASED PARCELLATION
  • INFERIOR PARIETAL LOBULE
  • PARKINSONS-DISEASE
  • BASAL GANGLIA
  • COGNITIVE IMPAIRMENT
  • DOPAMINERGIC-NEURONS
  • EMOTION RECOGNITION
  • GENDER-DIFFERENCES
  • NEGATIVE SYMPTOMS
  • SCHIZOPHRENIA

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