Key challenges in normal tissue complication probability model development and validation: towards a comprehensive strategy

Lisa Van den Bosch*, Ewoud Schuit, Hans Paul van der Laan, Johannes B Reitsma, Karel G M Moons, Roel J H M Steenbakkers, Frank J P Hoebers, Johannes A Langendijk, Arjen van der Schaaf

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Normal Tissue Complication Probability (NTCP) models can be used for treatment plan optimisation and patient selection for emerging treatment techniques. We discuss and suggest methodological approaches to address key challenges in NTCP model development and validation, including: missing data, non-linear response relationships, multicollinearity between predictors, overfitting, generalisability and the prediction of multiple complication grades at multiple time points. The methodological approaches chosen are aimed to improve the accuracy, transparency and robustness of future NTCP-models. We demonstrate our methodological approaches using clinical data.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalRadiotherapy and Oncology
Early online date23-Apr-2020
Publication statusPublished - Jul-2020

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