Kidney preservation

John O’Callaghan; Gabriel Oniscu; Henri Leuvenink; Peter J. Friend; Rutger J. Ploeg

doi:10.1016/B978-0-323-53186-3.00009-7

Kidney preservation

John O’Callaghan, Gabriel Oniscu, Henri Leuvenink, Peter J. Friend, Rutger J. Ploeg

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Abstract

Successful preservation of kidney allografts must counteract the cellular damage evolving after brain death or circulatory arrest. Static cold storage is the simplest method and has therefore been the most widely used. Several preservation fluids have been specially designed for this purpose, but a number of other fluids have been co-opted from other surgical specialties over the years. Hypothermic machine perfusion shows improved early graft function and graft survival compared to static cold storage, and particularly for extended criteria donor kidneys. Novel technologies are being developed to better assess the quality of the donor kidney and improve preservation, either using regional in situ normothermic perfusion or extracorporeal normothermic machine perfusion to allow further extension of the donor pool, without compromising outcomes.

Original language	English
Title of host publication	Kidney Transplantation - Principles and Practice
Editors	Stuart J. Knechtle, Lorna P. Marson, Peter J. Morris
Publisher	Elsevier
Pages	128-138
Number of pages	11
Edition	8
ISBN (Electronic)	9780323531863
DOIs	https://doi.org/10.1016/B978-0-323-53186-3.00009-7
Publication status	Published - 1-Jan-2019

Keywords

Kidney transplantation
Organ preservation
Organ preservation solutions
Perfusion

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10.1016/B978-0-323-53186-3.00009-7

Kidney preservationFinal publisher's version, 625 KBLicence: Taverne

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abstract = "Successful preservation of kidney allografts must counteract the cellular damage evolving after brain death or circulatory arrest. Static cold storage is the simplest method and has therefore been the most widely used. Several preservation fluids have been specially designed for this purpose, but a number of other fluids have been co-opted from other surgical specialties over the years. Hypothermic machine perfusion shows improved early graft function and graft survival compared to static cold storage, and particularly for extended criteria donor kidneys. Novel technologies are being developed to better assess the quality of the donor kidney and improve preservation, either using regional in situ normothermic perfusion or extracorporeal normothermic machine perfusion to allow further extension of the donor pool, without compromising outcomes.",

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T1 - Kidney preservation

AU - O’Callaghan, John

AU - Oniscu, Gabriel

AU - Leuvenink, Henri

AU - Friend, Peter J.

AU - Ploeg, Rutger J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Successful preservation of kidney allografts must counteract the cellular damage evolving after brain death or circulatory arrest. Static cold storage is the simplest method and has therefore been the most widely used. Several preservation fluids have been specially designed for this purpose, but a number of other fluids have been co-opted from other surgical specialties over the years. Hypothermic machine perfusion shows improved early graft function and graft survival compared to static cold storage, and particularly for extended criteria donor kidneys. Novel technologies are being developed to better assess the quality of the donor kidney and improve preservation, either using regional in situ normothermic perfusion or extracorporeal normothermic machine perfusion to allow further extension of the donor pool, without compromising outcomes.

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KW - Kidney transplantation

KW - Organ preservation

KW - Organ preservation solutions

KW - Perfusion

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M3 - Chapter

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BT - Kidney Transplantation - Principles and Practice

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A2 - Marson, Lorna P.

A2 - Morris, Peter J.

PB - Elsevier

ER -

Kidney preservation

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