TY - JOUR
T1 - Kidney Transplantation Improves Health-Related Quality of Life in Older Recipients
AU - de Boer, Silke E
AU - Knobbe, Tim J
AU - Kremer, Daan
AU - van Munster, Barbara C
AU - Nieuwenhuijs-Moeke, Gertrude J
AU - Pol, Robert A
AU - Bakker, Stephan J L
AU - Berger, Stefan P
AU - Sanders, Jan Stephan F
N1 - Copyright © 2024 de Boer, Knobbe, Kremer, van Munster, Nieuwenhuijs-Moeke, Pol, Bakker, Berger and Sanders.
PY - 2024/4/15
Y1 - 2024/4/15
N2 - Kidney transplantation is the best treatment for kidney failure in older patients. However, little is known regarding changes in health-related quality of life (HRQoL) from before to after transplantation and determinants of HRQoL in older kidney transplant recipients (KTR). We studied both, using data of older (≥65 years) patients waitlisted for kidney transplantation and older KTR 1 year after transplantation from the TransplantLines Biobank and Cohort Study. HRQoL was assessed using the SF-36 questionnaire. We included 145 older waitlisted patients (68% male, age 70 ± 4 years) and 115 older KTR at 1 year after transplantation (73% male, age 70 ± 4 years). Both mental (48.5 ± 8.4 versus 51.2 ± 7.7, p = 0.009) and physical (47.4 ± 8.5 versus 52.1 ± 7.2, p < 0.001) HRQoL were higher among included KTR, compared to the waitlisted patients. In paired analyses among 46 patients with HRQoL-data both before and after transplantation, there was a trend towards increased mental HRQoL (49.1 ± 8.4 to 51.6 ± 7.5, p = 0.054), and significantly increased physical HRQoL (48.1 ± 8.0 to 52.4 ± 6.7, p = 0.001) after transplantation. Among all assessed factors, the number of patient-reported immunosuppressive drug-related side effects was most strongly negatively associated with both mental and physical HRQoL. In conclusion, HRQoL is significantly higher among older KTR after kidney transplantation compared to older waitlisted patients.
AB - Kidney transplantation is the best treatment for kidney failure in older patients. However, little is known regarding changes in health-related quality of life (HRQoL) from before to after transplantation and determinants of HRQoL in older kidney transplant recipients (KTR). We studied both, using data of older (≥65 years) patients waitlisted for kidney transplantation and older KTR 1 year after transplantation from the TransplantLines Biobank and Cohort Study. HRQoL was assessed using the SF-36 questionnaire. We included 145 older waitlisted patients (68% male, age 70 ± 4 years) and 115 older KTR at 1 year after transplantation (73% male, age 70 ± 4 years). Both mental (48.5 ± 8.4 versus 51.2 ± 7.7, p = 0.009) and physical (47.4 ± 8.5 versus 52.1 ± 7.2, p < 0.001) HRQoL were higher among included KTR, compared to the waitlisted patients. In paired analyses among 46 patients with HRQoL-data both before and after transplantation, there was a trend towards increased mental HRQoL (49.1 ± 8.4 to 51.6 ± 7.5, p = 0.054), and significantly increased physical HRQoL (48.1 ± 8.0 to 52.4 ± 6.7, p = 0.001) after transplantation. Among all assessed factors, the number of patient-reported immunosuppressive drug-related side effects was most strongly negatively associated with both mental and physical HRQoL. In conclusion, HRQoL is significantly higher among older KTR after kidney transplantation compared to older waitlisted patients.
KW - Humans
KW - Kidney Transplantation
KW - Quality of Life
KW - Male
KW - Female
KW - Aged
KW - Waiting Lists
KW - Surveys and Questionnaires
KW - Cohort Studies
KW - Transplant Recipients/psychology
KW - Kidney Failure, Chronic/surgery
U2 - 10.3389/ti.2024.12071
DO - 10.3389/ti.2024.12071
M3 - Article
C2 - 38686099
SN - 0934-0874
VL - 37
JO - Transplant International
JF - Transplant International
M1 - 12071
ER -