Kinetics and 28-day test-retest repeatability and reproducibility of [C-11]UCB-J PET brain imaging

Hayel Tuncel*, Ronald Boellaard, Emma M Coomans, Erik FJ de Vries, Andor WJM Glaudemans, Paula Kopschina Feltes, David V García, Sander CJ Verfaillie, Emma E Wolters, Steven P Sweeney, J Michael Ryan, Magnus Ivarsson, Berkley A Lynch, Patrick Schober, Philip Scheltens, Robert C Schuit, Albert D Windhorst, Peter P De Deyn, Bart NM van Berckel, Sandeep SV Golla

*Corresponding author for this work

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Abstract

[C-11]UCB-J is a novel radioligand that binds to synaptic vesicle glycoprotein 2A (SV2A). The main objective of this study was to determine the 28-day test-retest repeatability (TRT) of quantitative [C-11]UCB-J brain positron emission tomography (PET) imaging in Alzheimer's disease (AD) patients and healthy controls (HCs). Nine HCs and eight AD patients underwent two 60 min dynamic [C-11]UCB-J PET scans with arterial sampling with an interval of 28 days. The optimal tracer kinetic model was assessed using the Akaike criteria (AIC). Micro-/macro-parameters such as tracer delivery (K-1) and volume of distribution (V-T) were estimated using the optimal model. Data were also analysed for simplified reference tissue model (SRTM) with centrum semi-ovale (white matter) as reference region. Based on AIC, both 1T2k_V-B and 2T4k_V-B described the [C-11]UCB-J kinetics equally well. Analysis showed that whole-brain grey matter TRT for V-T, DVR and SRTM BPND were -2.2% +/- 8.5, 0.4% +/- 12.0 and -8.0% +/- 10.2, averaged over all subjects. [C-11]UCB-J kinetics can be well described by a 1T2k_V-B model, and a 60 min scan duration was sufficient to obtain reliable estimates for both plasma input and reference tissue models. TRT for V-T, DVR and BPND was

Original languageEnglish
Pages (from-to)1338-1350
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Volume41
Issue number6
DOIs
Publication statusPublished - Jun-2021

Keywords

  • 11c
  • accepted 27 september 2020
  • alzheimer
  • kinetic modelling
  • pet
  • received 11 march 2020
  • revised 19 august 2020
  • s disease
  • sv2a
  • ucb-j

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