Lack of an Association Between Household Air Pollution Exposure and Previous Pulmonary Tuberculosis

Dennis Emuron, Trishul Siddharthan, Brooks Morgan, Suzanne L. Pollard, Matthew R. Grigsby, Dina Goodman, Muhammad Chowdhury, Adolfo Rubinstein, Vilma Irazola, Laura Gutierrez, J. Jaime Miranda, Antonio Bernabe-Ortiz, Dewan Alam, Bruce Kirenga, Rupert Jones, Frederik van Gemert, William Checkley*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    2 Citations (Scopus)

    Abstract

    Context Observational studies investigating household air pollution (HAP) exposure to biomass fuel smoke as a risk factor for pulmonary tuberculosis have reported inconsistent results. Objective To evaluate the association between HAP exposure and the prevalence of self-reported previous pulmonary tuberculosis. Design We analyzed pooled data including 12,592 individuals from five population-based studies conducted in Latin America, East Africa, and Southeast Asia from 2010 to 2015. We used multivariable logistic regression to model the association between HAP exposure and self-reported previous pulmonary tuberculosis adjusted for age, sex, tobacco smoking, body mass index, secondary education, site and country of residence. Results Mean age was 54.6 years (range of mean age across settings 43.8-59.6 years) and 48.6% were women (range of % women 38.3-54.5%). The proportion of participants reporting HAP exposure was 38.8% (range in % HAP exposure 0.48-99.4%). Prevalence of previous pulmonary tuberculosis was 2.7% (range of prevalence 0.6-6.9%). While participants with previous pulmonary tuberculosis had a lower pre-bronchodilator FEV1 (mean - 0.7 SDs, 95% CI - 0.92 to - 0.57), FVC (- 0.52 SDs, 95% CI - 0.69 to - 0.33) and FEV1/FVC (- 0.59 SDs, 95% CI - 0.76 to - 0.43) as compared to those who did not, we did not find an association between HAP exposure and previous pulmonary tuberculosis (adjusted odds ratio = 0.86; 95% CI 0.56-1.32). Conclusions There was no association between HAP exposure and self-reported previous pulmonary tuberculosis in five population-based studies conducted worldwide.

    Original languageEnglish
    Pages (from-to)793-801
    Number of pages9
    JournalLung
    Volume197
    Issue number6
    DOIs
    Publication statusPublished - Dec-2019

    Keywords

    • Biomass fuel
    • Tuberculosis burden
    • Cross-sectional study
    • SOLID-FUEL
    • RISK-FACTORS
    • BIOMASS FUEL
    • SMOKING
    • DETERMINANTS
    • PREVALENCE
    • DISEASE
    • GENDER
    • ADULTS
    • INDIA

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