Abstract
The invention relates to proteinaceous nanopores, nanopore systems and devices, and their application in single molecule analysis, such as detecting the presence, concentration and/or identity of a clinically relevant analyte in a complex sample. Provided is a sensor system comprising a nanopore embedded in an amphipathic or hydrophobic membrane separating a fluid filled chamber into a cis side and a trans side, wherein the nanopore is a conical shaped proteinaceous nanopore having a cis entrance of at least 11 nm, preferably about 12 to 20 nm, and a trans constriction of less than 5 nm, preferably about 2 to 4 nm.
| Original language | English |
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| Patent number | WO2024205413 |
| Priority date | 30/03/2023 |
| Filing date | 02/04/2024 |
| Publication status | Published - 3-Oct-2024 |