Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression

S. L. Gardiner*, M. J. van Belzen, M. W. Boogaard, W. M. C. van Roon-Mom, P.M. Rozing, A. M. van Hemert, J. H. Smit, A. T. F. Beekman, Gerard van Grootheest, R. A. Schoevers, R. C. Oude Voshaar, H. C. Comijs, B. W. J. H. Penninx, R. C. van der Mast, R. A. C. Roos, N. A. Aziz

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Depression is one of the most prevalent and debilitating psychiatric disorders worldwide. Recently, we showed that both relatively short and relatively long cytosine-adenine-guanine (CAG) repeats in the huntingtin gene (HTT) are associated with an increased risk of lifetime depression. However, to what extent the variations in CAG repeat length in the other eight polyglutamine disease-associated genes (PDAGs) are associated with depression is still unknown. We determined the CAG repeat sizes of ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and AR in two well-characterized Dutch cohorts-the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons-including 2165 depressed and 1058 non-depressed individuals-aged 18-93 years. The association between PDAG CAG repeat size and the risk for depression was assessed via binary logistic regression. We found that the odds ratio (OR) for lifetime depression was significantly higher for individuals with >10, compared with subjects with

Original languageEnglish
Article numbere1143
Number of pages7
JournalTranslational Psychiatry
Volume7
DOIs
Publication statusPublished - 6-Jun-2017

Keywords

  • DOMINANT CEREBELLAR-ATAXIA
  • MACHADO-JOSEPH-DISEASE
  • TATA-BINDING PROTEIN
  • RNA-POLYMERASE-II
  • SIMPLE SEQUENCE REPEATS
  • SPINOCEREBELLAR ATAXIA
  • TRINUCLEOTIDE REPEAT
  • MAJOR DEPRESSION
  • POLYGLUTAMINE EXPANSIONS
  • CLINICAL-MANIFESTATION

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