TY - JOUR
T1 - Laser Doppler Flowmetry Combined with Spectroscopy to Determine Peripheral Tissue Perfusion and Oxygen Saturation
T2 - A Pilot Study in Healthy Volunteers and Patients with Peripheral Arterial Disease
AU - Ma, Kirsten F.
AU - Kleiss, Simone F.
AU - Schuurmann, Richte C. L.
AU - Nijboer, Thomas S.
AU - El Moumni, Mostafa
AU - Bokkers, Reinoud P. H.
AU - de Vries, Jean-Paul P. M.
PY - 2022/6
Y1 - 2022/6
N2 - Background: In this study, we assessed the ability of the EPOS system (Perimed AB, Jarfalla, Stockholm, Sweden) to detect differences in tissue perfusion between healthy volunteers and patients with peripheral arterial disease (PAD) with different severity of disease.Methods: This singlecenter prospective pilot study included 10 healthy volunteers and 20 patients with PAD scheduled for endovascular therapy (EVT). EPOS measurements were performed at rest at 32 degrees C and 44 degrees C, followed by transcutaneous oxygen pressure (TcPo2) measurements. The measurements were performed on the dorsal and medial side of the foot, as well as the lateral side of the calf. EPOS parameters included hemoglobin oxygen saturation (HbSO(2)) and speed-resolved red blood cell (RBC) perfusion.Results: HbSO(2) at 44 degrees C was significantly different between the three groups for all measurement locations. The overall speed-resolved RBC perfusion at 44 degrees C was statistically significant between the groups on the dorsal and medial side of the foot but not on the calf. TcPO2 values were not significantly different between the three groups.Conclusions: This study demonstrates that the EPOS system can depict differences in tissue perfusion between healthy volunteers, patients with Fontaine class IIb PAD, and those with Fontaine class III or IV PAD but only after heating to 44 degrees C.
AB - Background: In this study, we assessed the ability of the EPOS system (Perimed AB, Jarfalla, Stockholm, Sweden) to detect differences in tissue perfusion between healthy volunteers and patients with peripheral arterial disease (PAD) with different severity of disease.Methods: This singlecenter prospective pilot study included 10 healthy volunteers and 20 patients with PAD scheduled for endovascular therapy (EVT). EPOS measurements were performed at rest at 32 degrees C and 44 degrees C, followed by transcutaneous oxygen pressure (TcPo2) measurements. The measurements were performed on the dorsal and medial side of the foot, as well as the lateral side of the calf. EPOS parameters included hemoglobin oxygen saturation (HbSO(2)) and speed-resolved red blood cell (RBC) perfusion.Results: HbSO(2) at 44 degrees C was significantly different between the three groups for all measurement locations. The overall speed-resolved RBC perfusion at 44 degrees C was statistically significant between the groups on the dorsal and medial side of the foot but not on the calf. TcPO2 values were not significantly different between the three groups.Conclusions: This study demonstrates that the EPOS system can depict differences in tissue perfusion between healthy volunteers, patients with Fontaine class IIb PAD, and those with Fontaine class III or IV PAD but only after heating to 44 degrees C.
KW - diffuse reflectance spectroscopy
KW - endovascular procedures
KW - laser Doppler flowmetry
KW - peripheral arterial disease
KW - tissue perfusion
KW - TRANSCUTANEOUS OXIMETRY
KW - MANAGEMENT
KW - CONSENSUS
U2 - 10.3390/jpm12060853
DO - 10.3390/jpm12060853
M3 - Article
C2 - 35743638
SN - 2075-4426
VL - 12
JO - Journal of personalized medicine
JF - Journal of personalized medicine
IS - 6
M1 - 853
ER -