Late (> 5 years) regional lymph node metastasis of oral squamous cell carcinoma (SCC), proven by p53 mutation analysis

J. Alain Kummer*, Robert J. J. Van Es, J.W.M. Hoekstra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)


Background: A late (>5 years) neck nodal metastasis of oral cancer, poses a problem to the clinician: is it a late metastasis or a metastasis of a (unknown) second primary tumour? Methods: A 50-year-old male was seen with a contralateral lymph node metastasis, 51/2 years after treatment of a pT2N1M0 carcinoma in the floor of the mouth. Both the late metastasis and the original tumour specimen were analysed for p53 mutations. Results: Both specimens showed an identical p53 mutation, thereby confirming the lymph node to be a late metastasis. Conclusions: A lymph node metastasis can occur more than 5 years after treatment of an oral squamous cell carcinoma. p53 mutation analysis is of help to discriminate it from a second primary tumour. (C) 2008 European Association for Cranio-Maxillofacial Surgery.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalJournal of Cranio-Maxillofacial Surgery
Issue number7
Publication statusPublished - Oct-2008


  • p53 mutation analysis
  • late metastasis
  • lymph node
  • second primary tumour
  • squamous cell carcinoma
  • IFN-beta-1a
  • HEAD
  • GENE

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