Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

LATER Study Group, Ellen Kilsdonk, Eline van Dulmen-den Broeder, Flora E. van Leeuwen, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Helena J. van der Pal, Dorine Bresters, A. B. Versluys, Rob Pieters, Michael Hauptmann, Monique W.M. Jaspers, Sebastian J.C. Neggers, Martine F. Raphael, Wim J.E. Tissing, Leontine C.M. Kremer*, Cécile M. Ronckers

*Corresponding author for this work

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Abstract

This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).

Original languageEnglish
Pages (from-to)413-424
Number of pages12
JournalCancer investigation
Volume40
Issue number5
DOIs
Publication statusPublished - 1-May-2022

Keywords

  • Childhood cancer survivors
  • late mortality

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