Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

LATER Study Group; Ellen Kilsdonk; Eline van Dulmen-den Broeder; Flora E. van Leeuwen; Marry M. van den Heuvel-Eibrink; Jacqueline J. Loonen; Helena J. van der Pal; Dorine Bresters; A. B. Versluys; Rob Pieters; Michael Hauptmann; Monique W.M. Jaspers; Sebastian J.C. Neggers; Martine F. Raphael; Wim J.E. Tissing; Leontine C.M. Kremer; Cécile M. Ronckers

doi:10.1080/07357907.2022.2034841

Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

LATER Study Group, Ellen Kilsdonk, Eline van Dulmen-den Broeder, Flora E. van Leeuwen, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Helena J. van der Pal, Dorine Bresters, A. B. Versluys, Rob Pieters, Michael Hauptmann, Monique W.M. Jaspers, Sebastian J.C. Neggers, Martine F. Raphael, Wim J.E. Tissing, Leontine C.M. Kremer^*, Cécile M. Ronckers

^*Corresponding author for this work

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Abstract

This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).

Original language	English
Pages (from-to)	413-424
Number of pages	12
Journal	Cancer investigation
Volume	40
Issue number	5
DOIs	https://doi.org/10.1080/07357907.2022.2034841
Publication status	Published - 1-May-2022

Keywords

Childhood cancer survivors
late mortality

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Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER CohortFinal publisher's version, 2.24 MBLicence: CC BY-NC-ND

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LATER Study Group, Kilsdonk, E., van Dulmen-den Broeder, E., van Leeuwen, F. E., van den Heuvel-Eibrink, M. M., Loonen, J. J., van der Pal, H. J., Bresters, D., Versluys, A. B., Pieters, R., Hauptmann, M., Jaspers, M. W. M., Neggers, S. J. C., Raphael, M. F., Tissing, W. J. E., Kremer, L. C. M., & Ronckers, C. M. (2022). Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort. Cancer investigation, 40(5), 413-424. https://doi.org/10.1080/07357907.2022.2034841

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title = "Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort",

abstract = "This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).",

keywords = "Childhood cancer survivors, late mortality",

author = "{LATER Study Group} and Ellen Kilsdonk and {van Dulmen-den Broeder}, Eline and {van Leeuwen}, {Flora E.} and {van den Heuvel-Eibrink}, {Marry M.} and Loonen, {Jacqueline J.} and {van der Pal}, {Helena J.} and Dorine Bresters and Versluys, {A. B.} and Rob Pieters and Michael Hauptmann and Jaspers, {Monique W.M.} and Neggers, {Sebastian J.C.} and Raphael, {Martine F.} and Tissing, {Wim J.E.} and Kremer, {Leontine C.M.} and Ronckers, {C{\'e}cile M.}",

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doi = "10.1080/07357907.2022.2034841",

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LATER Study Group, Kilsdonk, E, van Dulmen-den Broeder, E, van Leeuwen, FE, van den Heuvel-Eibrink, MM, Loonen, JJ, van der Pal, HJ, Bresters, D, Versluys, AB, Pieters, R, Hauptmann, M, Jaspers, MWM, Neggers, SJC, Raphael, MF, Tissing, WJE, Kremer, LCM & Ronckers, CM 2022, 'Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort', Cancer investigation, vol. 40, no. 5, pp. 413-424. https://doi.org/10.1080/07357907.2022.2034841

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T1 - Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

AU - LATER Study Group

AU - Kilsdonk, Ellen

AU - van Dulmen-den Broeder, Eline

AU - van Leeuwen, Flora E.

AU - van den Heuvel-Eibrink, Marry M.

AU - Loonen, Jacqueline J.

AU - van der Pal, Helena J.

AU - Bresters, Dorine

AU - Versluys, A. B.

AU - Pieters, Rob

AU - Hauptmann, Michael

AU - Jaspers, Monique W.M.

AU - Neggers, Sebastian J.C.

AU - Raphael, Martine F.

AU - Tissing, Wim J.E.

AU - Kremer, Leontine C.M.

AU - Ronckers, Cécile M.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).

AB - This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).

KW - Childhood cancer survivors

KW - late mortality

U2 - 10.1080/07357907.2022.2034841

DO - 10.1080/07357907.2022.2034841

M3 - Article

C2 - 35175864

AN - SCOPUS:85128800562

SN - 1532-4192

VL - 40

SP - 413

EP - 424

JO - Cancer investigation

JF - Cancer investigation

IS - 5

ER -

Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

Abstract

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