LC3-associated phagocytosis: a sorting mechanism for ubiquitinated membrane proteins?

Femmy C. Stempels; Geert van den Bogaart

doi:10.1080/27694127.2022.2040765

LC3-associated phagocytosis: a sorting mechanism for ubiquitinated membrane proteins?

Femmy C. Stempels, Geert van den Bogaart^*

^*Corresponding author for this work

Molecular Immunology & Microbiology

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

The process of LC3-associated phagocytosis (LAP) combines elements of phagocytosis and autophagy. LAP is involved in clearance of pathogens and cell debris, antigen presentation, and immune signaling. However, the mechanistic role of LAP is incompletely understood. Based on observations from our recent study, we propose that LAP might serve as a sorting mechanism to cluster proteins destined for degradation into discrete domains of the phagosomal membrane.

Original language	English
Pages (from-to)	25-28
Number of pages	4
Journal	Autophagy Reports
Volume	1
Issue number	1
DOIs	https://doi.org/10.1080/27694127.2022.2040765
Publication status	Published - 2022

Keywords

autophagy
inhibitor
LAP
LC3-associated phagocytosis
membrane domain

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LC3-associated phagocytosis: a sorting mechanism for ubiquitinated membrane proteins?Final publisher's version, 798 KBLicence: CC BY

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title = "LC3-associated phagocytosis: a sorting mechanism for ubiquitinated membrane proteins?",

abstract = "The process of LC3-associated phagocytosis (LAP) combines elements of phagocytosis and autophagy. LAP is involved in clearance of pathogens and cell debris, antigen presentation, and immune signaling. However, the mechanistic role of LAP is incompletely understood. Based on observations from our recent study, we propose that LAP might serve as a sorting mechanism to cluster proteins destined for degradation into discrete domains of the phagosomal membrane.",

keywords = "autophagy, inhibitor, LAP, LC3-associated phagocytosis, membrane domain",

author = "Stempels, \{Femmy C.\} and \{van den Bogaart\}, Geert",

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AU - van den Bogaart, Geert

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N2 - The process of LC3-associated phagocytosis (LAP) combines elements of phagocytosis and autophagy. LAP is involved in clearance of pathogens and cell debris, antigen presentation, and immune signaling. However, the mechanistic role of LAP is incompletely understood. Based on observations from our recent study, we propose that LAP might serve as a sorting mechanism to cluster proteins destined for degradation into discrete domains of the phagosomal membrane.

AB - The process of LC3-associated phagocytosis (LAP) combines elements of phagocytosis and autophagy. LAP is involved in clearance of pathogens and cell debris, antigen presentation, and immune signaling. However, the mechanistic role of LAP is incompletely understood. Based on observations from our recent study, we propose that LAP might serve as a sorting mechanism to cluster proteins destined for degradation into discrete domains of the phagosomal membrane.

KW - autophagy

KW - inhibitor

KW - LAP

KW - LC3-associated phagocytosis

KW - membrane domain

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DO - 10.1080/27694127.2022.2040765

M3 - Comment/Letter to the editor

AN - SCOPUS:105005015628

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EP - 28

JO - Autophagy Reports

JF - Autophagy Reports

IS - 1

ER -

LC3-associated phagocytosis: a sorting mechanism for ubiquitinated membrane proteins?

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Keywords

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