Leukocyte telomere length dynamics in women and men: Menopause vs age effects

Christine Dalgard, Athanase Benetos, Simon Verhulst, Carlos Labat, Jeremy D. Kark, Kaare Christensen, Masayuki Kimura, Kirsten Ohm Kyvik, Abraham Aviv*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

83 Citations (Scopus)
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Abstract

Background: A longer leukocyte telomere length (LTL) in women than men has been attributed to a slow rate of LTL attrition in women, perhaps due to high estrogen exposure during the premenopausal period.

Methods: To test this premise we performed a longitudinal study (an average follow-up of 12 years) in a subset of the population-based Danish National Twin Registry. Participants consisted of 405 women, aged 37.5 (range 18.0-64.3) years, and 329 men, aged 38.8 (range 18.0-58.5) years, at baseline examination.

Results: Women showed a longer LTL [kb +/- standard error(SE)] than men (baseline: 7.01 +/- 0.03 vs 6.87 +/- 0.04; follow-up: 6.79 +/- 0.03 vs 6.65 +/- 0.03; both P = 0.005). Women displayed deceleration of LTL attrition (bp/years +/- SE), as they transitioned from the premenopausal period (20.6 +/- 1.0) through the perimenopausal period (16.5 +/- 1.3) to the postmenopausal period (15.1 +/- 1.7). Age was not associated with LTL attrition in women after statistical control for menopausal status. Men, in contrast, displayed a trend for age-dependent increase in the rate of LTL attrition, which differed significantly from the pattern in women (P for interaction = 0.01).

Conclusions: Results indicate that the premenopausal period is expressed in a higher rate of LTL attrition than the postmenopausal period. They further suggest that the sex gap in LTL stems from earlier ages-the period of growth and development. The higher rate of LTL attrition in premenopausal women, we propose, might relate to estrogen-mediated increased turnover of erythrocytes, menstrual bleeding or both.

Original languageEnglish
Pages (from-to)1688-1695
Number of pages8
JournalInternational Journal of Epidemiology
Volume44
Issue number5
DOIs
Publication statusPublished - Oct-2015

Keywords

  • Telomeres
  • women
  • men
  • menopause
  • ESTROGEN
  • MORTALITY
  • ADULTS
  • TWINS

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