Lewis acid promoted dearomatization of naphthols

Syuzanna R Harutyunyan*, Kirill Kulish, Cosimo Boldrini, Marta Castiñeira Reis, Juana Pérez

*Corresponding author for this work

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Abstract

Two-step dearomative functionalization of naphthols promoted by Lewis acids and copper(I) catalysis was developed. Initially, Lewis acid complexation inverted the electronic properties of the ring and established an equilibrium with the dearomatized counterpart. Subsequent trapping of the dearomatized intermediate with organometallics as well as organophosphines was demonstrated and provided the corresponding dearomatized products.

Original languageEnglish
Pages (from-to)15843-15846
Number of pages4
JournalChemistry
Volume26
Issue number68
Early online date22-Sep-2020
DOIs
Publication statusPublished - 4-Dec-2020

Keywords

  • Lewis acids
  • copper catalysis
  • dearomatization
  • nucleophilic additions

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