Life in the slow lane: a multi-omics approach to molecular adaptions in hibernating Syrian hamster liver

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    Abstract

    Hibernation is a physiological and behavioral adaptation that is characterized by two phases: torpor and arousal. During torpor, the body temperature and metabolic rate of the animal decreases dramatically. Contrastingly, arousal periods are identified by a rapid recovery of metabolism and normal physiology. Investigating these adaptations can aid in the development of new drugs in diseases and conditions associated with suppressed metabolism followed by metabolic activation, such as during transplantation, heart failure, or trauma. We investigated the underlying physiological changes in the hibernating Syrian hamster to provide a better understanding of the regulation of transcription, the cell cycle, and mitochondrial suppression during hamster hibernation. We found that these mechanisms may be regulated by epigenetic factors, such as histone acetylation. These insights can be used to develop future methods for limiting or preventing ischemia-reperfusion damage in various medical conditions.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Henning, Rob, Supervisor
    • Rots, Marianne, Supervisor
    Award date13-Dec-2023
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-6483-579-3
    DOIs
    Publication statusPublished - 2023

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