Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome

J. K. Oosterhuis; G. van den Berg; W. E. Monteban-Kooistra; J. J. M. Ligtenberg; J. E. Tulleken; J. G. Zijlstra; John Meertens

Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome

J. K. Oosterhuis
, G. van den Berg
, W. E. Monteban-Kooistra
, J. J. M. Ligtenberg
, J. E. Tulleken
, J. G. Zijlstra^*
, John Meertens

^*Corresponding author for this work

Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Scopus)

90 Downloads (Pure)

Abstract

We describe two patients with a severe Cushing's syndrome due to ectopic production of ACTH. Both patients developed a life-threatening Pneumocystis jiroveci pneumonia (PCP) shortly after treatment of the hypercortisolism was started by means of inhibition of production of glucocorticoids and glucococorticoid. receptor blockade. We presume that the restored immune response elicited the clinical symptoms of the opportunistic, previously subclinical Pneumocystis jiroveci infection. The immunocompromised. state and the delicate glucocorticoid balance in patients with a severe Cushing's syndrome necessitate a specific diagnostic and therapeutic approach.

Original language	English
Pages (from-to)	215-217
Number of pages	3
Journal	Netherlands Journal of Medicine
Volume	65
Issue number	6
Publication status	Published - Jun-2007

Keywords

Cushing's syndrome
opportunistic infections
treatment
CARINII-PNEUMONIA
ADRENOCORTICOTROPIN
INFECTIONS
DIAGNOSIS
SECRETION
PATIENT

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title = "Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome",

abstract = "We describe two patients with a severe Cushing's syndrome due to ectopic production of ACTH. Both patients developed a life-threatening Pneumocystis jiroveci pneumonia (PCP) shortly after treatment of the hypercortisolism was started by means of inhibition of production of glucocorticoids and glucococorticoid. receptor blockade. We presume that the restored immune response elicited the clinical symptoms of the opportunistic, previously subclinical Pneumocystis jiroveci infection. The immunocompromised. state and the delicate glucocorticoid balance in patients with a severe Cushing's syndrome necessitate a specific diagnostic and therapeutic approach.",

keywords = "Cushing's syndrome, opportunistic infections, treatment, CARINII-PNEUMONIA, ADRENOCORTICOTROPIN, INFECTIONS, DIAGNOSIS, SECRETION, PATIENT",

author = "Oosterhuis, \{J. K.\} and \{van den Berg\}, G. and Monteban-Kooistra, \{W. E.\} and Ligtenberg, \{J. J. M.\} and Tulleken, \{J. E.\} and Zijlstra, \{J. G.\} and John Meertens",

year = "2007",

month = jun,

language = "English",

volume = "65",

pages = "215--217",

journal = "Netherlands Journal of Medicine",

issn = "0300-2977",

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TY - JOUR

T1 - Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome

AU - Oosterhuis, J. K.

AU - van den Berg, G.

AU - Monteban-Kooistra, W. E.

AU - Ligtenberg, J. J. M.

AU - Tulleken, J. E.

AU - Zijlstra, J. G.

AU - Meertens, John

PY - 2007/6

Y1 - 2007/6

N2 - We describe two patients with a severe Cushing's syndrome due to ectopic production of ACTH. Both patients developed a life-threatening Pneumocystis jiroveci pneumonia (PCP) shortly after treatment of the hypercortisolism was started by means of inhibition of production of glucocorticoids and glucococorticoid. receptor blockade. We presume that the restored immune response elicited the clinical symptoms of the opportunistic, previously subclinical Pneumocystis jiroveci infection. The immunocompromised. state and the delicate glucocorticoid balance in patients with a severe Cushing's syndrome necessitate a specific diagnostic and therapeutic approach.

AB - We describe two patients with a severe Cushing's syndrome due to ectopic production of ACTH. Both patients developed a life-threatening Pneumocystis jiroveci pneumonia (PCP) shortly after treatment of the hypercortisolism was started by means of inhibition of production of glucocorticoids and glucococorticoid. receptor blockade. We presume that the restored immune response elicited the clinical symptoms of the opportunistic, previously subclinical Pneumocystis jiroveci infection. The immunocompromised. state and the delicate glucocorticoid balance in patients with a severe Cushing's syndrome necessitate a specific diagnostic and therapeutic approach.

KW - Cushing's syndrome

KW - opportunistic infections

KW - treatment

KW - CARINII-PNEUMONIA

KW - ADRENOCORTICOTROPIN

KW - INFECTIONS

KW - DIAGNOSIS

KW - SECRETION

KW - PATIENT

M3 - Article

C2 - 17587649

SN - 0300-2977

VL - 65

SP - 215

EP - 217

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

IS - 6

ER -

Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome

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