TY - JOUR
T1 - Lifestyle factors and incident multimorbidity related to chronic disease
T2 - a population-based cohort study
AU - Du, Yihui
AU - de Bock, Geertruida H.
AU - Vonk, Judith M.
AU - Pham, An Thanh
AU - van der Ende, M. Yldau
AU - Snieder, Harold
AU - Smidt, Nynke
AU - Krabbe, Paul F.M.
AU - Alizadeh, Behrooz Z.
AU - Lunter, Gerton
AU - Corpeleijn, Eva
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Background: Multimorbidity is linked to poor quality of life, and increased healthcare costs, and multimorbidity risk is potentially mitigated by a healthy lifestyle. This study evaluated the individual and joint contributions of an extensive set of lifestyle factors to the development of multimorbidity. Methods: A prospective study of 133,719 adults (age 45.2 ± 12.9, range 18–93 years) from the Dutch Lifelines cohort assessed the influence of lifestyle factors on multimorbidity, defined as having at least two of four major chronic diseases, using Cox regression models and population attributable fractions (PAFs). Lifestyle-related factors included diet quality, physical activity, TV watching, substance use (alcohol, smoking), sleep (duration, medication), stress (acute, chronic) and social connectedness (social contacts, marital status). Results: Over a median follow-up of 3.4 years, 3687 (12.5%) of the 29,545 participants with a chronic disease at baseline developed multimorbidity, compared to 434 (0.4%) of the 104,174 without a chronic disease. Key lifestyle factors linked to multimorbidity included smoking, prolonged TV watching, and stress, with hazard ratios indicating a higher risk in both groups. Additionally, high alcohol consumption and inadequate sleep duration were found to increase multimorbidity risk specifically in those with a chronic disease. Lifestyle factors jointly accounted for 34.4% (PAF, 95%CI 28.8%–73.5%) (with baseline morbidity) and 55.6% (95%CI 17.2%–48.5%) (without) of multimorbidity cases, with smoking as the primary contributor. Conclusions: Lifestyle factors, particularly smoking, alcohol consumption, TV watching, stress, and sleep, significantly contribute to the development of multimorbidity. The study underscores the importance of targeted prevention in public health and healthcare settings to manage and prevent multimorbidity.
AB - Background: Multimorbidity is linked to poor quality of life, and increased healthcare costs, and multimorbidity risk is potentially mitigated by a healthy lifestyle. This study evaluated the individual and joint contributions of an extensive set of lifestyle factors to the development of multimorbidity. Methods: A prospective study of 133,719 adults (age 45.2 ± 12.9, range 18–93 years) from the Dutch Lifelines cohort assessed the influence of lifestyle factors on multimorbidity, defined as having at least two of four major chronic diseases, using Cox regression models and population attributable fractions (PAFs). Lifestyle-related factors included diet quality, physical activity, TV watching, substance use (alcohol, smoking), sleep (duration, medication), stress (acute, chronic) and social connectedness (social contacts, marital status). Results: Over a median follow-up of 3.4 years, 3687 (12.5%) of the 29,545 participants with a chronic disease at baseline developed multimorbidity, compared to 434 (0.4%) of the 104,174 without a chronic disease. Key lifestyle factors linked to multimorbidity included smoking, prolonged TV watching, and stress, with hazard ratios indicating a higher risk in both groups. Additionally, high alcohol consumption and inadequate sleep duration were found to increase multimorbidity risk specifically in those with a chronic disease. Lifestyle factors jointly accounted for 34.4% (PAF, 95%CI 28.8%–73.5%) (with baseline morbidity) and 55.6% (95%CI 17.2%–48.5%) (without) of multimorbidity cases, with smoking as the primary contributor. Conclusions: Lifestyle factors, particularly smoking, alcohol consumption, TV watching, stress, and sleep, significantly contribute to the development of multimorbidity. The study underscores the importance of targeted prevention in public health and healthcare settings to manage and prevent multimorbidity.
KW - Chronic disease
KW - Chronic stress
KW - Cohort
KW - Lifestyle factors
KW - Multimorbidity
KW - TV watching
UR - http://www.scopus.com/inward/record.url?scp=85211184423&partnerID=8YFLogxK
U2 - 10.1007/s10433-024-00833-x
DO - 10.1007/s10433-024-00833-x
M3 - Article
AN - SCOPUS:85211184423
SN - 1613-9372
VL - 21
JO - European Journal of Ageing
JF - European Journal of Ageing
M1 - 37
ER -