TY - JOUR
T1 - Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European prospective investigation into cancer and nutrition (EPIC) study
AU - Weikert, Cornelia
AU - Dietrich, Thomas
AU - Boeing, Heiner
AU - Bergmann, Manuela M.
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Francoise
AU - Allen, Naomi
AU - Key, Tim
AU - Lund, Eiliv
AU - Olsen, Anja
AU - Tjonneland, Anne
AU - Overvad, Kim
AU - Rohrmann, Sabine
AU - Linseisen, Jakob
AU - Pischon, Tobias
AU - Trichopoulou, Antonia
AU - Weinehall, Lars
AU - Johansson, Ingegerd
AU - Sanchez, Maria-Jose
AU - Agudo, Antonio
AU - Barricarte, Aurelio
AU - Amiano, Pilar
AU - Chirlaque, Maria-Dolores
AU - Ramon Quiros, J.
AU - Wirfalt, Elisabet
AU - Peeters, Petra H.
AU - Bueno-de-Mesquita, H. Bas
AU - Vrieling, Alina
AU - Pala, Valeria
AU - Palli, Domenico
AU - Vineis, Paolo
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Bingham, Sheila
AU - Khaw, Kay-Tee
AU - Norat, Teresa
AU - Jenab, Mazda
AU - Ferrari, Pietro
AU - Slimani, Nadia
AU - Riboli, Elio
PY - 2009/7/15
Y1 - 2009/7/15
N2 - Recent alcohol consumption is all established risk factor for squamous cell carcinoma (SCC) or the upper aero-digestive tract. In contrast, the role or lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data oil alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression vas applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were significantly increased for men who drank 30.1-60.0 g/day (RR 1.65, 95% confidence interval: 1.00-2.71), 60.1-96.0 g/day (RR 2.20, 95%CI 1.23-3.95), and >96.0 g/day, (RR 4.63, 95% CI 2.52-8.48), and for former drinkers (RR 4.14, 95% CI 2.38-7.19). These risk estimates did not considerably change when baseline alcohol intake was analyzed. Compared to women who drank 0.1-6.0 g/day alcohol intake at lifetime, the RR were significantly increased for women who drank >30 g/d (RR 6.05, 95% CI 2.98-12.3). Applying similar categories, the relative risk for baseline alcohol intake was 3.26 (95%CI 1.82-5.87). We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life. (C) 2009 UICC
AB - Recent alcohol consumption is all established risk factor for squamous cell carcinoma (SCC) or the upper aero-digestive tract. In contrast, the role or lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data oil alcohol use are available in 271,253 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 2,330,381 person years, 392 incident SCC cases (279 men and 113 women) were identified. Cox regression vas applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Compared to men who drank 0.1-6.0 g/day alcohol at lifetime, the relative risks (RR) for developing SCC were significantly increased for men who drank 30.1-60.0 g/day (RR 1.65, 95% confidence interval: 1.00-2.71), 60.1-96.0 g/day (RR 2.20, 95%CI 1.23-3.95), and >96.0 g/day, (RR 4.63, 95% CI 2.52-8.48), and for former drinkers (RR 4.14, 95% CI 2.38-7.19). These risk estimates did not considerably change when baseline alcohol intake was analyzed. Compared to women who drank 0.1-6.0 g/day alcohol intake at lifetime, the RR were significantly increased for women who drank >30 g/d (RR 6.05, 95% CI 2.98-12.3). Applying similar categories, the relative risk for baseline alcohol intake was 3.26 (95%CI 1.82-5.87). We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life. (C) 2009 UICC
KW - cohort study
KW - epidemiology
KW - squamous cell carcinoma
KW - esophagus
KW - larynx
KW - oral cavity
KW - pharynx
KW - GENDER-DIFFERENCES
KW - COMPETING RISKS
KW - POOLED ANALYSIS
KW - NECK-CANCER
KW - DRINKING
KW - TOBACCO
KW - CONSUMPTION
KW - POPULATION
KW - PROJECT
KW - HEAD
U2 - 10.1002/ijc.24393
DO - 10.1002/ijc.24393
M3 - Article
SN - 0020-7136
VL - 125
SP - 406
EP - 412
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 2
ER -