Ligand-free copper(I) catalyzed N- and O-arylation of aryl halides

Elena Sperotto, Johannes G. de Vries, Gerard P.M. van Klink, Gerard van Koten

Research output: Contribution to journalArticleAcademic

70 Citations (Scopus)
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Abstract

A simple and industrially viable protocol for C–N and C–O coupling is reported here. Arylation of phenol, benzylamine and imidazole with aryl bromides is achieved using ligand-free Cu(I) halide salts in low catalytic amount (2.5 mol %).
Original languageEnglish
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number41
DOIs
Publication statusPublished - 2007

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