Ligand-free palladium catalysed Heck reaction of methyl 2-acetamido acrylate and aryl bromides as key step in the synthesis of enantiopure substituted phenylalanines

Charlotte E. Willans, Jan M.C.A. Mulders, Johannes G. de Vries, André H.M. de Vries

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A range of substituted aryl bromides were coupled with methyl 2-acetamido acrylate using ligand-free palladium catalysis. Subsequently asymmetric hydrogenation with Rh/MonoPhos yielded substituted phenylalanines in high enantioselectivities (e.e. 92-99%).
Original languageEnglish
Number of pages4
JournalJournal of Organometallic Chemistry
Issue number2
Publication statusPublished - 2003

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