Ligand-targeted liposomes directed against pathological vasculature

G Molema; TLM ten Hagen; Adrienne P.C.A. Janssen; AJ Schraa; RJ Kok; GA Koning; G Storm

doi:10.1081/LPR-120004785

Ligand-targeted liposomes directed against pathological vasculature

G Molema, TLM ten Hagen, Adrienne P.C.A. Janssen, AJ Schraa, RJ Kok, GA Koning, G Storm

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Abstract

The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.

Original language	English
Pages (from-to)	129-135
Number of pages	7
Journal	Journal of Liposome Research
Volume	12
Issue number	1-2
DOIs	https://doi.org/10.1081/LPR-120004785
Publication status	Published - 2002
Event	5th International Conference on Liposome Advances - Duration: 17-Dec-2001 → 21-Dec-2001

Keywords

angiogenesis
integrins
RGD-peptide
drug targeting
liposomes
ANGIOGENESIS
CANCER
INFLAMMATION
MECHANISMS
THERAPIES
DISEASES
AGENTS

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Ligand-targeted liposomes directed against pathological vasculatureFinal publisher's version, 195 KBLicence: Taverne

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@article{cf45f4a84d65460686ca04aefc9b369a,

title = "Ligand-targeted liposomes directed against pathological vasculature",

abstract = "The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.",

keywords = "angiogenesis, integrins, RGD-peptide, drug targeting, liposomes, ANGIOGENESIS, CANCER, INFLAMMATION, MECHANISMS, THERAPIES, DISEASES, AGENTS",

author = "G Molema and {ten Hagen}, TLM and Janssen, {Adrienne P.C.A.} and AJ Schraa and RJ Kok and GA Koning and G Storm",

year = "2002",

doi = "10.1081/LPR-120004785",

language = "English",

volume = "12",

pages = "129--135",

journal = "Journal of Liposome Research",

issn = "0898-2104",

publisher = "Taylor & Francis Group",

number = "1-2",

note = "5th International Conference on Liposome Advances ; Conference date: 17-12-2001 Through 21-12-2001",

}

TY - JOUR

T1 - Ligand-targeted liposomes directed against pathological vasculature

AU - Molema, G

AU - ten Hagen, TLM

AU - Janssen, Adrienne P.C.A.

AU - Schraa, AJ

AU - Kok, RJ

AU - Koning, GA

AU - Storm, G

PY - 2002

Y1 - 2002

N2 - The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.

AB - The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.

KW - angiogenesis

KW - integrins

KW - RGD-peptide

KW - drug targeting

KW - liposomes

KW - ANGIOGENESIS

KW - CANCER

KW - INFLAMMATION

KW - MECHANISMS

KW - THERAPIES

KW - DISEASES

KW - AGENTS

U2 - 10.1081/LPR-120004785

DO - 10.1081/LPR-120004785

M3 - Article

SN - 0898-2104

VL - 12

SP - 129

EP - 135

JO - Journal of Liposome Research

JF - Journal of Liposome Research

IS - 1-2

T2 - 5th International Conference on Liposome Advances

Y2 - 17 December 2001 through 21 December 2001

ER -

Ligand-targeted liposomes directed against pathological vasculature

Abstract

Keywords

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