Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling

Chiharu Ota; Hoeke A Baarsma; Darcy E Wagner; Anne Hilgendorff; Melanie Königshoff

doi:10.1186/s40348-016-0062-6

Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling

Chiharu Ota, Hoeke A Baarsma, Darcy E Wagner, Anne Hilgendorff, Melanie Königshoff

Research output: Contribution to journal › Review article › peer-review

41 Citations (Scopus)

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Abstract

Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.

Original language	English
Article number	34
Number of pages	13
Journal	Molecular and cellular pediatrics
Volume	3
Issue number	1
DOIs	https://doi.org/10.1186/s40348-016-0062-6
Publication status	Published - Dec-2016
Externally published	Yes

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Journal Article

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Linking bronchopulmonary dysplasia to adult chronic lung diseasesFinal publisher's version, 1.07 MBLicence: CC BY

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title = "Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling",

abstract = "Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.",

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AU - Ota, Chiharu

AU - Baarsma, Hoeke A

AU - Wagner, Darcy E

AU - Hilgendorff, Anne

AU - Königshoff, Melanie

PY - 2016/12

Y1 - 2016/12

N2 - Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.

AB - Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.

KW - Review

KW - Journal Article

U2 - 10.1186/s40348-016-0062-6

DO - 10.1186/s40348-016-0062-6

M3 - Review article

C2 - 27718180

SN - 2194-7791

VL - 3

JO - Molecular and cellular pediatrics

JF - Molecular and cellular pediatrics

IS - 1

M1 - 34

ER -

Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling

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