Lipid-DNAs as Solubilizers of mTHPC

Yun Liu, Jan Willem de Vries, Qing Liu, Alwin M Hartman, Gerhard D Wieland, Sebastian Wieczorek, Hans G Börner, Arno Wiehe, Eric Buhler, Marc C A Stuart, Wesley R Browne, Andreas Herrmann*, Anna K H Hirsch

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
458 Downloads (Pure)

Abstract

Hydrophobic drug candidates require innovative formulation agents. We designed and synthesized lipid-DNA polymers containing varying numbers of hydrophobic alkyl chains. The hydrophobicity of these amphiphiles is easily tunable by introducing a defined number of alkyl chain-modified nucleotides during standard solid-phase synthesis of DNA using an automated DNA synthesizer. We observed that the resulting self-assembled micelles solubilize the poorly water-soluble drug, meta-tetra-hydroxyphenyl-chlorin (mTHPC) used in photodynamic therapy (PDT) with high loading concentrations and loading capacities. A cell viability study showed that mTHPC-loaded micelles exhibit good biocompatibility without irradiation, and high PDT efficacy upon irradiation. Lipid-DNAs provide a novel class of drug-delivery vehicle, and hybridization of DNA offers a potentially facile route for further functionalization of the drug-delivery system with, for instance, targeting or imaging moieties.

Original languageEnglish
Pages (from-to)798-802
Number of pages5
JournalChemistry
Volume24
Issue number4
Early online date18-Dec-2017
DOIs
Publication statusPublished - 19-Jan-2018

Keywords

  • Journal Article
  • AMPHIPHILES
  • THERAPY
  • DRUG-DELIVERY
  • POLYMERIC MICELLES
  • PHOTOSENSITIZER

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