Lipid profile in breast cancer: From signaling pathways to treatment strategies

Hennrique Taborda Ribas, Mari C. Sogayar, Amalia M. Dolga, Sheila M.B. Winnischofer*, Marina Trombetta-Lima*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Breast cancer is the most prevalent cancer in women. Metabolic abnormalities, particularly increased lipid synthesis and uptake, impact the onset and progression of the disease. However, the influence of lipid metabolism in breast cancer varies according to the disease stage and patient's hormone status. In postmenopausal patients, obesity is associated with a higher risk and poor prognosis of luminal tumors, while in premenopausal individuals, it is correlated to BRCA mutated tumors. In fact, the tumor's lipid profile may be used to distinguish between HER2+, luminal and BRCA-mutated tumors. Moreover, drug resistance was associated with increased fatty acid synthesis and alterations in membrane composition, impacting its fluidity and spatial subdomains such as lipid rafts. Here, we discuss the subtype-specific lipid metabolism alterations found in breast cancer and the potentiality of its modulation in a clinical setting.

Original languageEnglish
Pages (from-to)118-129
Number of pages12
JournalBiochimie
Volume219
DOIs
Publication statusPublished - Apr-2024

Keywords

  • Breast cancer
  • Lipid profile
  • Lipidomic

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