Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

Daniel T. Schuhle; Patrick van Rijn; Sophie Laurent; Luce Vander Elst; Robert N. Muller; Marc C. A. Stuart; Juergen Schatze; Joop A. Peters

doi:10.1039/c0cc00107d

Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

Daniel T. Schuhle, Patrick van Rijn, Sophie Laurent, Luce Vander Elst, Robert N. Muller, Marc C. A. Stuart, Juergen Schatze, Joop A. Peters^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.

Original language	English
Pages (from-to)	4399-4401
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	24
DOIs	https://doi.org/10.1039/c0cc00107d
Publication status	Published - 2010

Keywords

PARAMAGNETIC LIPOSOMES
RELAXIVITY
COMPLEXES

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Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative
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title = "Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI",

abstract = "Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.",

keywords = "PARAMAGNETIC LIPOSOMES, RELAXIVITY, COMPLEXES",

author = "Schuhle, {Daniel T.} and {van Rijn}, Patrick and Sophie Laurent and {Vander Elst}, Luce and Muller, {Robert N.} and Stuart, {Marc C. A.} and Juergen Schatze and Peters, {Joop A.}",

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language = "English",

volume = "46",

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T1 - Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

AU - Schuhle, Daniel T.

AU - van Rijn, Patrick

AU - Laurent, Sophie

AU - Vander Elst, Luce

AU - Muller, Robert N.

AU - Stuart, Marc C. A.

AU - Schatze, Juergen

AU - Peters, Joop A.

PY - 2010

Y1 - 2010

N2 - Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.

AB - Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.

KW - PARAMAGNETIC LIPOSOMES

KW - RELAXIVITY

KW - COMPLEXES

U2 - 10.1039/c0cc00107d

DO - 10.1039/c0cc00107d

M3 - Article

SN - 1359-7345

VL - 46

SP - 4399

EP - 4401

JO - Chemical Communications

JF - Chemical Communications

IS - 24

ER -

Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

Abstract

Keywords

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