Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection Sites

Da-Yuan Wang; Guang Yang; Henny C. van Der Mei; Yijin Ren; Henk J. Busscher; Linqi Shi

doi:10.1002/anie.202106329

Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection Sites

Da-Yuan Wang, Guang Yang, Henny C. van Der Mei^*, Yijin Ren, Henk J. Busscher^*, Linqi Shi^*

^*Corresponding author for this work

Man, Biomaterials and Microbes (MBM)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A lipid named DCPA was synthesized under microwave-assisted heating. DCPA possesses a pyridine betaine, hydrophilic group that can be complexed with water through hydrogen bonding (DCPA-H2O). DCPA-H2O liposomes became protonated relatively fast already at pH

Original language	English
Pages (from-to)	17714-17719
Number of pages	6
Journal	Angewandte Chemie-International Edition
Volume	60
Issue number	32
DOIs	https://doi.org/10.1002/anie.202106329
Publication status	Published - 2-Aug-2021

Keywords

hydrogen bonding
pH-responsive
pyridine betaine
self-targeting
zwitterionic lipids
NANOPARTICLES
CIRCULATION
ACTIVATION
STRATEGY
BEHAVIOR
TIME

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Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection SitesFinal publisher's version, 1.68 MBLicence: CC BY-NC-ND

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title = "Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection Sites",

abstract = "A lipid named DCPA was synthesized under microwave-assisted heating. DCPA possesses a pyridine betaine, hydrophilic group that can be complexed with water through hydrogen bonding (DCPA-H2O). DCPA-H2O liposomes became protonated relatively fast already at pH",

keywords = "hydrogen bonding, pH-responsive, pyridine betaine, self-targeting, zwitterionic lipids, NANOPARTICLES, CIRCULATION, ACTIVATION, STRATEGY, BEHAVIOR, TIME",

author = "Da-Yuan Wang and Guang Yang and {van Der Mei}, {Henny C.} and Yijin Ren and Busscher, {Henk J.} and Linqi Shi",

year = "2021",

month = aug,

day = "2",

doi = "10.1002/anie.202106329",

language = "English",

volume = "60",

pages = "17714--17719",

journal = "Angewandte Chemie-International Edition",

issn = "1433-7851",

publisher = "WILEY-V C H VERLAG GMBH",

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TY - JOUR

T1 - Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection Sites

AU - Wang, Da-Yuan

AU - Yang, Guang

AU - van Der Mei, Henny C.

AU - Ren, Yijin

AU - Busscher, Henk J.

AU - Shi, Linqi

PY - 2021/8/2

Y1 - 2021/8/2

N2 - A lipid named DCPA was synthesized under microwave-assisted heating. DCPA possesses a pyridine betaine, hydrophilic group that can be complexed with water through hydrogen bonding (DCPA-H2O). DCPA-H2O liposomes became protonated relatively fast already at pH

AB - A lipid named DCPA was synthesized under microwave-assisted heating. DCPA possesses a pyridine betaine, hydrophilic group that can be complexed with water through hydrogen bonding (DCPA-H2O). DCPA-H2O liposomes became protonated relatively fast already at pH

KW - hydrogen bonding

KW - pH-responsive

KW - pyridine betaine

KW - self-targeting

KW - zwitterionic lipids

KW - NANOPARTICLES

KW - CIRCULATION

KW - ACTIVATION

KW - STRATEGY

KW - BEHAVIOR

KW - TIME

U2 - 10.1002/anie.202106329

DO - 10.1002/anie.202106329

M3 - Article

SN - 1433-7851

VL - 60

SP - 17714

EP - 17719

JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

IS - 32

ER -

Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection Sites

Abstract

Keywords

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