Lipotoxicity and the role of maternal nutrition

M. G. M. Pruis, P. A. van Ewijk, V. B. Schrauwen-Hinderling, T. Ploesch*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

11 Citations (Scopus)

Abstract

Intrauterine malnutrition predisposes the offspring towards the development of type 2 diabetes and cardiovascular disease. To explain this association, the Developmental Origins of Health and Disease hypothesis was introduced, meaning that subtle environmental changes during embryonic and foetal development can influence post-natal physiological functions. Different mechanisms, including epigenetics, are thought to be involved in this foetal programming, but the link between epigenetics and disease is missing. There is increasing evidence that ectopic lipid accumulation and/or lipotoxicity is induced by foetal programming. The aim of this review is to provide insights into the mechanisms underlying lipotoxicity through programming, which contributes to the increase in hepatic and cardiac metabolic risk.

Original languageEnglish
Pages (from-to)296-306
Number of pages11
JournalActa physiologica
Volume210
Issue number2
DOIs
Publication statusPublished - Feb-2014

Keywords

  • foetal programming
  • heart failure
  • lipotoxicity
  • non-alcoholic steatohepatitis
  • obesity
  • HIGH-FAT DIET
  • PROTEIN-RESTRICTED DIET
  • BLOOD-PRESSURE
  • INSULIN-RESISTANCE
  • BIRTH-WEIGHT
  • NUTRIENT RESTRICTION
  • METABOLIC-SYNDROME
  • GENE-EXPRESSION
  • CARDIOVASCULAR DYSFUNCTION
  • DEVELOPMENTAL ORIGINS

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