Lithium use and the risk of fractures

Ingeborg Wilting, Frank de Vries, Brahm M. K. S. Thio, Cyrus Cooper, Eibert R. Heerdink, Hubert G. M. Leutkens, Willem A. Nolen, Antoine C. G. Egberts, Tjeerd P. van Staa*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)

Abstract

A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use. (c) 2007 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)1252-1258
Number of pages7
JournalBone
Volume40
Issue number5
DOIs
Publication statusPublished - May-2007

Keywords

  • fractures
  • lithium
  • mania
  • depression
  • PRACTICE RESEARCH DATABASE
  • MESENCHYMAL STEM-CELLS
  • PARATHYROID-HORMONE
  • BIPOLAR DISORDER
  • SUICIDE RISK
  • HIP FRACTURE
  • LONG-TERM
  • DISCONTINUATION
  • CARBONATE
  • DIFFERENTIATION

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