Liver transplantation in patients with post-hepatectomy liver failure: A Northern European multicenter cohort study

Ernesto Sparrelid; Trygve Thorsen; Christina Sauter; Carl Jorns; Per Stål; Arno Nordin; Marieke T. de Boer; Carlijn Buis; Sheraz Yaqub; Nicolai A. Schultz; Peter N. Larsen; Ville Sallinen; Pål Dag Line; Stefan Gilg

doi:10.1016/j.hpb.2021.12.005

Liver transplantation in patients with post-hepatectomy liver failure: A Northern European multicenter cohort study

Ernesto Sparrelid^*
, Trygve Thorsen
, Christina Sauter
, Carl Jorns
, Per Stål
, Arno Nordin
, Marieke T. de Boer
, Carlijn Buis
, Sheraz Yaqub
, Nicolai A. Schultz
, Peter N. Larsen
, Ville Sallinen
, Pål Dag Line
, Stefan Gilg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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113 Downloads (Pure)

Abstract

Background: Liver transplantation (LTX) has been described as a rescue treatment option in severe, intractable post-hepatectomy liver failure (PHLF), but is not considered to be indicated for this condition by many hepatobiliary and transplant surgeons. In this article we describe the clinical experience of five northern European tertiary centers in using LTX to treat selected patients with severe PHLF.

Methods: All patients subjected to LTX due to PHLF at the participating centers were identified from prospective clinical databases. Preoperative variables, surgical outcome (both resection surgery and LTX) and follow-up data were assessed.

Results: A total of 10 patients treated with LTX due to severe PHLF from September 2008 to May 2020 were identified and included in the study. All patients but one were male and the median age was 70 years (range 49–72). In all patients the indication for liver resection was suspected malignancy, but in six patients post-resection pathology revealed benign or pre-malignant disease. There was no 90-day mortality after LTX. Patients were followed for a median of 49 months (13–153) and eight patients were alive without recurrence at last follow-up.

Discussion: In selected patients with PHLF LTX can be a life-saving procedure with low short-term risk.

Original language	English
Pages (from-to)	1138–1144
Number of pages	7
Journal	HPB
Volume	24
Issue number	7
DOIs	https://doi.org/10.1016/j.hpb.2021.12.005
Publication status	Published - Jul-2022

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Sparrelid, E., Thorsen, T., Sauter, C., Jorns, C., Stål, P., Nordin, A., de Boer, M. T., Buis, C., Yaqub, S., Schultz, N. A., Larsen, P. N., Sallinen, V., Line, P. D., & Gilg, S. (2022). Liver transplantation in patients with post-hepatectomy liver failure: A Northern European multicenter cohort study. HPB, 24(7), 1138–1144. https://doi.org/10.1016/j.hpb.2021.12.005

@article{0f78272ff3464d74bb34e24effd80b74,

title = "Liver transplantation in patients with post-hepatectomy liver failure: A Northern European multicenter cohort study",

abstract = "Background: Liver transplantation (LTX) has been described as a rescue treatment option in severe, intractable post-hepatectomy liver failure (PHLF), but is not considered to be indicated for this condition by many hepatobiliary and transplant surgeons. In this article we describe the clinical experience of five northern European tertiary centers in using LTX to treat selected patients with severe PHLF.Methods: All patients subjected to LTX due to PHLF at the participating centers were identified from prospective clinical databases. Preoperative variables, surgical outcome (both resection surgery and LTX) and follow-up data were assessed.Results: A total of 10 patients treated with LTX due to severe PHLF from September 2008 to May 2020 were identified and included in the study. All patients but one were male and the median age was 70 years (range 49–72). In all patients the indication for liver resection was suspected malignancy, but in six patients post-resection pathology revealed benign or pre-malignant disease. There was no 90-day mortality after LTX. Patients were followed for a median of 49 months (13–153) and eight patients were alive without recurrence at last follow-up.Discussion: In selected patients with PHLF LTX can be a life-saving procedure with low short-term risk.",

author = "Ernesto Sparrelid and Trygve Thorsen and Christina Sauter and Carl Jorns and Per St{\aa}l and Arno Nordin and \{de Boer\}, \{Marieke T.\} and Carlijn Buis and Sheraz Yaqub and Schultz, \{Nicolai A.\} and Larsen, \{Peter N.\} and Ville Sallinen and Line, \{P{\aa}l Dag\} and Stefan Gilg",

note = "Funding Information: The authors have no conflict of interest to declare and have received no funding for the work with this article. Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2022",

month = jul,

doi = "10.1016/j.hpb.2021.12.005",

language = "English",

volume = "24",

pages = "1138–1144",

journal = "HPB",

issn = "1365-182X",

publisher = "ELSEVIER SCI LTD",

number = "7",

}

TY - JOUR

T1 - Liver transplantation in patients with post-hepatectomy liver failure

T2 - A Northern European multicenter cohort study

AU - Sparrelid, Ernesto

AU - Thorsen, Trygve

AU - Sauter, Christina

AU - Jorns, Carl

AU - Stål, Per

AU - Nordin, Arno

AU - de Boer, Marieke T.

AU - Buis, Carlijn

AU - Yaqub, Sheraz

AU - Schultz, Nicolai A.

AU - Larsen, Peter N.

AU - Sallinen, Ville

AU - Line, Pål Dag

AU - Gilg, Stefan

PY - 2022/7

Y1 - 2022/7

N2 - Background: Liver transplantation (LTX) has been described as a rescue treatment option in severe, intractable post-hepatectomy liver failure (PHLF), but is not considered to be indicated for this condition by many hepatobiliary and transplant surgeons. In this article we describe the clinical experience of five northern European tertiary centers in using LTX to treat selected patients with severe PHLF.Methods: All patients subjected to LTX due to PHLF at the participating centers were identified from prospective clinical databases. Preoperative variables, surgical outcome (both resection surgery and LTX) and follow-up data were assessed.Results: A total of 10 patients treated with LTX due to severe PHLF from September 2008 to May 2020 were identified and included in the study. All patients but one were male and the median age was 70 years (range 49–72). In all patients the indication for liver resection was suspected malignancy, but in six patients post-resection pathology revealed benign or pre-malignant disease. There was no 90-day mortality after LTX. Patients were followed for a median of 49 months (13–153) and eight patients were alive without recurrence at last follow-up.Discussion: In selected patients with PHLF LTX can be a life-saving procedure with low short-term risk.

AB - Background: Liver transplantation (LTX) has been described as a rescue treatment option in severe, intractable post-hepatectomy liver failure (PHLF), but is not considered to be indicated for this condition by many hepatobiliary and transplant surgeons. In this article we describe the clinical experience of five northern European tertiary centers in using LTX to treat selected patients with severe PHLF.Methods: All patients subjected to LTX due to PHLF at the participating centers were identified from prospective clinical databases. Preoperative variables, surgical outcome (both resection surgery and LTX) and follow-up data were assessed.Results: A total of 10 patients treated with LTX due to severe PHLF from September 2008 to May 2020 were identified and included in the study. All patients but one were male and the median age was 70 years (range 49–72). In all patients the indication for liver resection was suspected malignancy, but in six patients post-resection pathology revealed benign or pre-malignant disease. There was no 90-day mortality after LTX. Patients were followed for a median of 49 months (13–153) and eight patients were alive without recurrence at last follow-up.Discussion: In selected patients with PHLF LTX can be a life-saving procedure with low short-term risk.

U2 - 10.1016/j.hpb.2021.12.005

DO - 10.1016/j.hpb.2021.12.005

M3 - Article

AN - SCOPUS:85123219828

SN - 1365-182X

VL - 24

SP - 1138

EP - 1144

JO - HPB

JF - HPB

IS - 7

ER -

Liver transplantation in patients with post-hepatectomy liver failure: A Northern European multicenter cohort study

Abstract

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