Local innate and adaptive immune responses regulate inflammatory cell influx into the lungs after vaccination with formalin inactivated RSV

Debby Kruijsen, Marcel A. Schijf, Michaël Lukens, Nathalie O. van Uden, Jan L. Kimpen, Frank E. Coenjaerts, Grada M. van Bleek*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Abstract

Inactivated respiratory syncytial virus (RSV) vaccines tend to predispose for immune mediated enhanced disease, characterized by Th2 responses and airway hypersensitivity reactions. We show in a C57BL/6 mouse model that the early innate response elicited by the challenge virus (RSV versus influenza virus) influences the outcome of the Th1/Th2 balance in the lung after intramuscular priming with inactivated vaccine. Priming of CD4(+)/IFN-gamma(+) T cells by mature dendritic cells administered intravenously and/or priming of a virus specific CD8(+) T cell response ameliorated the Th2-mediated inflammatory response in the lung, suggesting that vaccination procedures are feasible that prevent vaccine induced immune pathology. (C) 2011 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)2730-2741
Number of pages12
JournalVaccine
Volume29
Issue number15
DOIs
Publication statusPublished - 24-Mar-2011

Keywords

  • Respiratory syncytial virus
  • Vaccination
  • Allergy
  • RESPIRATORY SYNCYTIAL VIRUS
  • DUST MITE ALLERGEN
  • CD8(+) T-CELLS
  • DENDRITIC CELLS
  • BALB/C MICE
  • COTTON RATS
  • ANTIGEN PRESENTATION
  • PULMONARY PATHOLOGY
  • AIRWAY INFLAMMATION
  • INHALED ANTIGEN

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