Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints

R J Sinke; B de Leeuw; H A Janssen; D O Weghuis; R F Suijkerbuijk; A M Meloni; S Gilgenkrantz; W Berger; H H Ropers; A A Sandberg

Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints

R J Sinke
, B de Leeuw
, H A Janssen
, D O Weghuis
, R F Suijkerbuijk
, A M Meloni
, S Gilgenkrantz
, W Berger
, H H Ropers
, A A Sandberg

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X;1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.

Original language	English
Pages (from-to)	305-8
Number of pages	4
Journal	HUMAN GENETICS
Volume	92
Issue number	3
Publication status	Published - 1-Oct-1993

Keywords

Animals
Blotting, Southern
Carcinoma, Renal Cell
Chromosome Mapping
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 18
Cricetinae
Cricetulus
Genetic Markers
Humans
Hybrid Cells
Male
Sarcoma, Synovial
Translocation, Genetic
Tumor Cells, Cultured
X Chromosome

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title = "Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints",

abstract = "A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X;1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.",

keywords = "Animals, Blotting, Southern, Carcinoma, Renal Cell, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 18, Cricetinae, Cricetulus, Genetic Markers, Humans, Hybrid Cells, Male, Sarcoma, Synovial, Translocation, Genetic, Tumor Cells, Cultured, X Chromosome",

author = "Sinke, \{R J\} and \{de Leeuw\}, B and Janssen, \{H A\} and Weghuis, \{D O\} and Suijkerbuijk, \{R F\} and Meloni, \{A M\} and S Gilgenkrantz and W Berger and Ropers, \{H H\} and Sandberg, \{A A\}",

year = "1993",

month = oct,

day = "1",

language = "English",

volume = "92",

pages = "305--8",

journal = "HUMAN GENETICS",

issn = "0340-6717",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints

AU - Sinke, R J

AU - de Leeuw, B

AU - Janssen, H A

AU - Weghuis, D O

AU - Suijkerbuijk, R F

AU - Meloni, A M

AU - Gilgenkrantz, S

AU - Berger, W

AU - Ropers, H H

AU - Sandberg, A A

PY - 1993/10/1

Y1 - 1993/10/1

N2 - A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X;1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.

AB - A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X;1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.

KW - Animals

KW - Blotting, Southern

KW - Carcinoma, Renal Cell

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 1

KW - Chromosomes, Human, Pair 18

KW - Cricetinae

KW - Cricetulus

KW - Genetic Markers

KW - Humans

KW - Hybrid Cells

KW - Male

KW - Sarcoma, Synovial

KW - Translocation, Genetic

KW - Tumor Cells, Cultured

KW - X Chromosome

M3 - Article

C2 - 8406438

SN - 0340-6717

VL - 92

SP - 305

EP - 308

JO - HUMAN GENETICS

JF - HUMAN GENETICS

IS - 3

ER -

Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints

Abstract

Keywords

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