Locally Advanced Colon Cancer: Evaluation of Current Clinical Practice and Treatment Outcomes at the Population Level

Charlotte E. L. Klaver, Lieke Gietelink, Willem A. Bemelman, Michel W. J. M. Wouters, Theo Wiggers, Rob A. E. M. Tollenaar, Pieter J. Tanis*, Dutch Surgical Colorectal Audit Gr

*Corresponding author for this work

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    12 Citations (Scopus)

    Abstract

    Background: The goal of this study was to evaluate current clinical practice and treatment outcomes regarding locally advanced colon cancer (LACC) at the population level. Methods: Data were used from the Dutch Surgical Colorectal Audit from 2009 to 2014. A total of 34,527 patients underwent resection for non-LACC and 6,918 for LACC, which was defined as cT4 and/or pT4 stage. LACC was divided into those with multivisceral resection (LACC-MV; n=3,385) and without (LACC-noMV; n=1,595). Guideline adherence, treatment strategy, and short-term outcomes were evaluated. Results: Guideline adherence was >90% regarding preoperative imaging and 80% regarding preoperative multidisciplinary team (MDT) discussion. In the elective setting, neoadjuvant chemoradiotherapy (chemoRT) was applied in 6.2% of the cT4 cases, and neoadjuvant chemotherapy in 4.0%. RO resection rates were 99%, 91%, and 87% in patients with non-LACC, LACCnoMV, and LACC-MV, respectively (P

    Original languageEnglish
    Pages (from-to)181-190
    Number of pages10
    JournalJournal of the national comprehensive cancer network
    Volume15
    Issue number2
    DOIs
    Publication statusPublished - Feb-2017

    Keywords

    • ADVANCED COLORECTAL-CANCER
    • MULTIVISCERAL RESECTION
    • OPEN SURGERY
    • NEOADJUVANT CHEMORADIOTHERAPY
    • LAPAROSCOPIC RESECTION
    • MARGIN INVOLVEMENT
    • T4
    • PANCREATICODUODENECTOMY
    • CARCINOMA

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