Long-term cerebral imaging after pre-eclampsia

A. M. Aukes, J. C. De Groot, M. J. Wiegman, J. G. Aarnoudse, G. S. Sanwikarja, G. G. Zeeman*

*Corresponding author for this work

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    Abstract

    Please cite this paper as: Aukes A, De Groot J, Wiegman M, Aarnoudse J, Sanwikarja G, Zeeman G. Long-term cerebral imaging after pre-eclampsia. BJOG 2012;119:11171122. Objective Formerly eclamptic women demonstrate cerebral white matter lesions (WMLs) several years following the index pregnancy. The pathophysiology is unclear and may be related to the predisposition for cerebrovascular/cardiovascular disease in such women and/or the occurrence of posterior reversible encephalopathy syndrome whilst pregnant. The aim of this study was to assess the presence and severity of WMLs and their relationship with the severity of the neurological symptoms during the index pregnancy and several current cardiovascular risk factors in formerly pre-eclamptic women. Design This was a retrospective cohort study. Setting The Neuroimaging Centre at the School for Behavioural and Cognitive Neurosciences, Groningen, the Netherlands. Population Seventy-three formerly pre-eclamptic women were matched for age (37 +/- 6 years) and elapsed time since index pregnancy (5.1 +/- 3.7 years) with parous control women. Methods Cerebral magnetic resonance imaging scans were performed on cases and controls. Scans were rated by a neuroradiologist blind to the patient category. Main outcome measures The presence and severity of cerebral WMLs. Results Formerly pre-eclamptic women had WMLs significantly more often (37%) and more severely (mean, 0.11; median, 0.00; range, 02.34 ml) than controls (21%, P = 0.04; mean, 0.015; median, 0.00; range, 00.13 ml; P = 0.02). Current hypertension and a history of early-onset pre-eclampsia (

    Original languageEnglish
    Pages (from-to)1117-1122
    Number of pages6
    JournalBJOG-an International Journal Of Obstetrics And Gynaecology
    Volume119
    Issue number9
    DOIs
    Publication statusPublished - Aug-2012

    Keywords

    • Cardiovascular disease
    • cerebral imaging
    • hypertension
    • long-term consequences
    • posterior reversible encephalopathy syndrome
    • pre-eclampsia
    • pregnancy
    • WHITE-MATTER HYPERINTENSITIES
    • CARDIOVASCULAR-DISEASE
    • BLOOD-PRESSURE
    • LATER LIFE
    • PREGNANCY
    • ECLAMPSIA
    • LESIONS
    • ENCEPHALOPATHY
    • METAANALYSIS
    • HYPERTENSION

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