Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome

Research output: Contribution to journalArticleAcademicpeer-review

54 Citations (Scopus)
64 Downloads (Pure)

Abstract

Objective The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. We aim to unravel interactions between diet, gut microbiota and their functional ability to induce intestinal inflammation.

Design We investigated the relation between 173 dietary factors and the microbiome of 1425 individuals spanning four cohorts: Crohn's disease, ulcerative colitis, irritable bowel syndrome and the general population. Shotgun metagenomic sequencing was performed to profile gut microbial composition and function. Dietary intake was assessed through food frequency questionnaires. We performed unsupervised clustering to identify dietary patterns and microbial clusters. Associations between diet and microbial features were explored per cohort, followed by a meta-analysis and heterogeneity estimation.

Results We identified 38 associations between dietary patterns and microbial clusters. Moreover, 61 individual foods and nutrients were associated with 61 species and 249 metabolic pathways in the meta-analysis across healthy individuals and patients with IBS, Crohn's disease and UC (false discovery rate

Conclusion We identified dietary patterns that consistently correlate with groups of bacteria with shared functional roles in both, health and disease. Moreover, specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects. We propose microbial mechanisms through which the diet affects inflammatory responses in the gut as a rationale for future intervention studies.

Original languageEnglish
Pages (from-to)1287-1298
Number of pages12
JournalGut
Volume70
Issue number7
Early online date2-Apr-2021
DOIs
Publication statusPublished - Jul-2021

Keywords

  • RED WINE POLYPHENOLS
  • BOWEL-DISEASE
  • FIBER
  • RISK
  • COLITIS
  • BARRIER
  • MARKERS
  • IMPACT

Cite this