Long-term prognostic value of quantitative myocardial perfusion in patients with chest pain and normal coronary arteries

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
170 Downloads (Pure)

Abstract

BACKGROUND: Patients with chest pain and no obstructive coronary artery disease have shown a high incidence of major adverse cardiovascular events (MACE). We evaluated the role of absolute myocardial perfusion quantification in predicting all-cause mortality and MACE during long-term follow-up in this group of patients.

METHODS: We studied 79 patients who underwent Nitrogen-13 ammonia PET for quantification of global myocardial blood flow (MBF) and myocardial flow reserve (MFR) due to suspected impaired myocardial perfusion. Patients with coronary artery disease (i.e., > 30% stenosis in one or more coronary arteries) were excluded. We assessed all-cause mortality and MACE. MACE was defined as the composite incidence of death, myocardial infarction (MI), or hospitalization due to heart failure.

RESULTS: Median follow-up was 8 (IQR: 3-14) years. Univariate Cox regression showed that only MFR (P = 0.01) was a predictor of all-cause mortality. Univariate Cox regression analysis showed that both MFR and Stress MBF were predictors of the composite endpoint of MACE (P < 0.001 and P = 0.01, respectively).

CONCLUSION: Quantitative assessment of myocardial perfusion may predict all-cause mortality and MACE in patients with chest pain and normal coronary arteries in the long-term follow-up.

Original languageEnglish
Pages (from-to)1844-1852
Number of pages9
JournalJournal of Nuclear Cardiology
Volume26
Issue number6
Early online date4-Oct-2018
DOIs
Publication statusPublished - Dec-2019

Keywords

  • Microvascular dysfunction
  • PET
  • Myocardial blood flow
  • Diagnostic and prognostic application
  • POSITRON-EMISSION-TOMOGRAPHY
  • MICROVASCULAR DYSFUNCTION
  • FLOW RESERVE
  • BLOOD-FLOW
  • DISEASE
  • QUANTIFICATION
  • EVENTS
  • ANGINA
  • RISK

Cite this