Long-term survivors of ovarian malignancies after cisplatin-based chemotherapy: cardiovascular risk factors and signs of vascular damage

FYFL de Vos, J Nuver, PHB Willemse, AGJ van der Zee, J Messerschraidt, JGM Burgerhof, EGE de Vries, JA Gietema*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Abstract

dMale germ cell tumour patients treated with cisplatin-based chemotherapy frequently develop cardiovascular risk factors and disease, but sparse information is available about long-term complications of this type of chemotherapy in women. We investigated the prevalence of cardiovascular risk factors and vascular damage in 21 women (median age 39 years; range 26-57 years) with an epithelial or germ cell tumour of the ovary cured by cisplatin-based chemotherapy after a median follow-up of 14 years (range 3-21 years). Hypercholesterolaemia was present in 62%, obesity in 24%, hypertension in 14%, insulin resistance in 14%, and microalbuminuria in 24% of patients. Microalbuminuria was more frequent in long-term cancer survivors than in a female background population with a similar age (23.8 versus 3.2%; P <0.05). A substantial portion of young female patients cured by cisplatin-based chemotherapy are likely to develop cardiovascular risk factors and signs of endothelial damage at an early stage. (C) 2004 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)696-700
Number of pages5
JournalEuropean Journal of Cancer
Volume40
Issue number5
DOIs
Publication statusPublished - Mar-2004

Keywords

  • germ cell turnout
  • ovaries
  • cis-platinum
  • cardiovascular diseases
  • endothelium
  • GERM-CELL TUMORS
  • GYNECOLOGIC-ONCOLOGY-GROUP
  • TESTICULAR-CANCER
  • REPRODUCTIVE FUNCTION
  • BLEOMYCIN
  • ETOPOSIDE
  • TOXICITY
  • DISEASE
  • VINBLASTINE
  • REPLACEMENT

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