Long-Term Type 1 Diabetes Enhances In-Stent Restenosis after Aortic Stenting in Diabetes-Prone BB Rats

Geanina Onuta, Hendrik C. Groenewegen, Flip A. Klatter, Mark Walther Boer, Maaike Goris, Harry van Goor, Anton J. M. Roks, Jan Rozing, Bart J. G. L. de Smet, Jan-Luuk Hillebrands*

*Corresponding author for this work

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Abstract

Type 1 diabetic patients have increased risk of developing in-stent restenosis following endovascular stenting. Underlying pathogenetic mechanisms are not fully understood partly due to the lack of a relevant animal model to study the effect(s) of long-term autoimmune diabetes on development of in-stent restenosis. We here describe the development of in-stent restenosis in long-term (similar to 7 months) spontaneously diabetic and age-matched, thymectomized, nondiabetic Diabetes Prone BioBreeding (BBDP) rats (n = 6-7 in each group). Diabetes was suboptimally treated with insulin and was characterized by significant hyperglycaemia, polyuria, proteinuria, and increased HbA(1c) levels. Stented abdominal aortas were harvested 28 days after stenting. Computerized morphometric analysis revealed significantly increased neointima formation in long-term diabetic rats compared with nondiabetic controls. In conclusion, long-term autoimmune diabetes in BBDP rats enhances in-stent restenosis. This model can be used to study the underlying pathogenetic mechanisms of diabetes-enhanced in-stent restenosis as well as to test new therapeutic modalities.

Original languageEnglish
Article number396734
Number of pages8
JournalJournal of biomedicine and biotechnology
DOIs
Publication statusPublished - 2011

Keywords

  • CORONARY-ARTERY-DISEASE
  • SMOOTH-MUSCLE-CELLS
  • DRUG ELUTING STENTS
  • OBESE ZUCKER RATS
  • NEOINTIMAL RESPONSE
  • CEREBROSPINAL-FLUID
  • MELLITUS
  • INJURY
  • MODEL
  • ANGIOPLASTY

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