Long-Term Visual Functioning After Eclampsia

Marjon J. Wiegman*, Jan C. de Groot, Nomdo M. Jansonius, Jan G. Aarnoudse, Henk Groen, Marijke M. Faas, Gerda G. Zeeman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

OBJECTIVE: Complete neurocognitive recovery after eclampsia has been questioned with the expression of neurocognitive deficits by affected women and demonstration of cerebral white matter lesions on magnetic resonance imaging years after eclampsia. We hypothesized that formerly eclamptic women may experience impaired vision-related quality of life (QOL) and visual field loss as a result of the presence of such lesions in the cerebral visual areas.

METHODS: Using the National Eye Institute Visual Function Questionnaire-39/Nederlands questionnaire, vision-related QOL was compared between formerly eclamptic women and control participants after normotensive pregnancies. Furthermore, in formerly eclamptic women, visual fields were assessed using automated perimetry, and presence of white matter lesions was evaluated using cerebral magnetic resonance imaging. Presence of a relationship between these lesions and National Eye Institute Visual Function Questionnaire-39/Nederlands scores was estimated.

RESULTS: Forty-seven formerly eclamptic women and 47 control participants participated 10.1 +/- 5.2 and 11.5 +/- 7.8 years after their index pregnancy, respectively. Composite scores and 4 out of 12 National Eye Institute Visual Function Questionnaire-39/Nederlands subscale scores were significantly lower in formerly eclamptic women than in control participants (P

CONCLUSION: Formerly eclamptic women express lower vision-related QOL than control participants, which seemed at least partly related to the presence of white matter lesions. However, such women do not have unconscious visual field loss. Vision-related QOL impairment expressed by formerly eclamptic women may therefore be related to problems with higher-order visual functions.

Original languageEnglish
Pages (from-to)959-966
Number of pages8
JournalObstetrics and Gynecology
Volume119
Issue number5
DOIs
Publication statusPublished - May-2012

Keywords

  • QUALITY-OF-LIFE
  • POSTERIOR LEUKOENCEPHALOPATHY SYNDROME
  • FIELD DEFECTS
  • HOMONYMOUS HEMIANOPIA
  • STROKE PATIENTS
  • PREGNANCY
  • LESIONS
  • ROTTERDAM
  • ENCEPHALOPATHY
  • IMPAIRMENT

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